Reactome | AKT phosphorylates PHF20

AKT phosphorylates PHF20

Stable Identifier

R-HSA-6805785

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        AKT phosphorylates PHF20 (Homo sapiens)

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AKT phosphorylates PHF20 on serine residue S291 (Li et al. 2013). AKT-mediated PHF20 phosphorylation inhibits DNA damage-induced stabilitzation of TP53 protein (Li et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
22975685	PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage Piao, L, Kim, Y, Kim, SH, Park, J, Brazil, DP, Hong, J, Park, J, Yoo, BC, Kong, G, Seok, JH, Choi, SW, Hur, GM, Park, KA, Zhang, T, Li, Y, Hemmings, BA	Cell. Signal.	2013