Reactome | SNAP25 [specific granule membrane]

SNAP25 [specific granule membrane]

Stable Identifier

R-HSA-6806154

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Synaptosomal-associated protein 25

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External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

BioGPS Gene:6616 SNAP25

COSMIC (genes):SNAP25 SNAP25

CTD Gene:6616 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

HGNC:11132 SNAP25

KEGG:hsa:6616 SNAP25

Monarch:6616 SNAP25

NCBI Gene:6616 SNAP25

OMIM:600322 SNAP25

UCSC:P60880 SNAP25

Reference Transcript

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

SNAP25 [plasma membrane]

SNAP25 [tertiary granule membrane]

SNAP25(199-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25(198-206) [cytosol]

SNAP25(1-197) [plasma membrane]

Inferred To

Snap24 [specific granule membrane] (Drosophila melanogaster)

snap25a [specific granule membrane] (Danio rerio)

Snap25 [specific granule membrane] (Drosophila melanogaster)

Snap25 [specific granule membrane] (Mus musculus)

Snap25 [specific granule membrane] (Rattus norvegicus)

SEC9 [specific granule membrane] (Saccharomyces cerevisiae)

aex-4 [specific granule membrane] (Caenorhabditis elegans)

SPO20 [specific granule membrane] (Saccharomyces cerevisiae)

SNAP25 [specific granule membrane] (Bos taurus)

SNAP25 [specific granule membrane] (Canis familiaris)

SNAP25 [specific granule membrane] (Dictyostelium discoideum)

SNAP25 [specific granule membrane] (Gallus gallus)

SNAP25 [specific granule membrane] (Plasmodium falciparum)

SNAP25 [specific granule membrane] (Sus scrofa)

cspA [specific granule membrane] (Dictyostelium discoideum)

ric-4 [specific granule membrane] (Caenorhabditis elegans)

snap25 [specific granule membrane] (Xenopus tropicalis)

Homologues of SNAP25 [specific granule membrane] (Caenorhabditis elegans)

Homologues of SNAP25 [specific granule membrane] (Dictyostelium discoideum)

Homologues of SNAP25 [specific granule membrane] (Drosophila melanogaster)

Homologues of SNAP25 [specific granule membrane] (Saccharomyces cerevisiae)

sec9 [specific granule membrane] (Schizosaccharomyces pombe)

Modified Residues

Name

S-palmitoyl-L-cysteine at 85

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 88

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 90

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 92

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

NP_001309831.1, NP_001309832.1, XP_005260865.1, XP_016883511.1, XP_016883510.1, NP_001309835.1, NP_570824.1, NP_001309836.1, NP_001309837.1, NP_001309834.1, NP_003072.2, NP_001309833.1, NP_001309838.1, NP_001309839.1

OpenTargets

ENSG00000132639

ENSEMBL

ENST00000691353, ENSP00000509287, ENST00000689757, ENSP00000508939, ENSP00000510219, ENSP00000508837, ENSP00000307341, ENST00000689858, ENSP00000254976, ENST00000706269, ENST00000304886, ENSP00000510558, ENSP00000516314, ENST00000693325, ENST00000692411, ENST00000691161, ENSP00000510663, ENSP00000509312, ENSP00000508541, ENSP00000509759, ENST00000687785, ENSP00000510109, ENST00000254976, ENSG00000132639, ENST00000690812, ENST00000685131, ENST00000691665

GeneCards

SNAP25

HPA

ENSG00000132639-SNAP25

PRO

P60880

Pharos - Targets

P60880

GlyGen

P60880

Orphanet

SNAP25

HMDB Protein

HMDBP02940

PDB

3DDB, 3RK2, 3DDA, 6JLH, 3RK3, 5W7J, 5W7I, 8BAN, 2N1T, 3RL0, 1KIL, 8BAV, 1XTG, 3ZUR

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:O75558 STX11			0.553	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.547	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.527	2
UniProt:P84077 ARF1	2	ARF1 [Golgi membrane] (R-HSA-199971) ARF1 [cytosol] (R-HSA-200826)	0.512	5
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.502	2
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2

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