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MME [secretory granule membrane]
Stable Identifier
R-HSA-6806156
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
Neprilysin, NEP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
MME [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08473 MME
Gene Names
MME, EPN
Chain
initiator methionine:, chain:2-750
Reference Genes
BioGPS Gene:4311 MME
COSMIC (genes):MME MME
CTD Gene:4311 MME
dbSNP Gene:4311 MME
ENSEMBL:ENSG00000196549 MME
ENSEMBL_homo_sapiens_GENE:ENSG00000196549.13 MME
HGNC:7154 MME
KEGG Gene (Homo sapiens):4311 MME
Monarch:4311 MME
NCBI Gene:4311 MME
OMIM:120520 MME
UCSC:P08473 MME
Reference Transcript
RefSeq:XM_011512857.2 MME
RefSeq:XM_006713647.3 MME
RefSeq:NM_007288.2 MME
RefSeq:NM_007289.2 MME
RefSeq:NM_000902.3 MME
RefSeq:NM_007287.2 MME
RefSeq:XM_011512855.2 MME
RefSeq:XM_006713646.3 MME
RefSeq:XM_011512856.2 MME
Other Identifiers
11720022_a_at
11741562_a_at
11747693_a_at
11755860_a_at
1389_at
16947173
203434_PM_s_at
203434_s_at
203435_PM_s_at
203435_s_at
2648678
2648679
2648680
2648681
2648682
2648683
2648684
2648685
2648686
2648687
2648688
2648705
2648707
2648708
2648709
2648710
2648715
2648716
2648717
2648718
2648720
2648721
2648724
2648725
2648727
2648729
2648731
2648732
2648734
2648736
2648742
2648743
2648744
2648745
2648746
4311
8083494
A_23_P212061
A_24_P260101
A_33_P3290707
A_33_P3370094
GE58450
GO:0001786
GO:0001822
GO:0001890
GO:0003824
GO:0004175
GO:0004222
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005769
GO:0005794
GO:0005802
GO:0005886
GO:0005903
GO:0005925
GO:0006508
GO:0006518
GO:0007611
GO:0008021
GO:0008233
GO:0008237
GO:0008238
GO:0008270
GO:0008289
GO:0009986
GO:0010814
GO:0010815
GO:0016020
GO:0016485
GO:0016787
GO:0019233
GO:0023052
GO:0030154
GO:0030163
GO:0030324
GO:0030424
GO:0030425
GO:0030667
GO:0031410
GO:0042277
GO:0042447
GO:0042803
GO:0043025
GO:0043226
GO:0043627
GO:0044306
GO:0045121
GO:0045202
GO:0046449
GO:0046872
GO:0048856
GO:0050435
GO:0050769
GO:0050877
GO:0051604
GO:0061837
GO:0070012
GO:0070062
GO:0071345
GO:0071492
GO:0071493
GO:0090399
GO:0097242
GO:0098793
GO:0140096
GO:0150094
GO:1900273
GO:1901612
HMNXSV003013972
Hs.1298.2.S1_3p_a_at
ILMN_1678170
ILMN_1696162
ILMN_1751943
ILMN_1786319
J03779_at
PH_hs_0023672
TC03000846.hg
g6042199_3p_a_at
Participates
as a member of
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
Other forms of this molecule
MME [plasma membrane]
Inferred To
Nepl18 [secretory granule membrane]
(Drosophila melanogaster)
nep-4 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl5 [secretory granule membrane]
(Drosophila melanogaster)
frma [secretory granule membrane]
(Drosophila melanogaster)
Nepl13 [secretory granule membrane]
(Drosophila melanogaster)
goe [secretory granule membrane]
(Drosophila melanogaster)
Nepl14 [secretory granule membrane]
(Drosophila melanogaster)
nep-26 [secretory granule membrane]
(Caenorhabditis elegans)
Homologues of MME [secretory granule membrane]
(Caenorhabditis elegans)
Homologues of MME [secretory granule membrane]
(Drosophila melanogaster)
nep-9 [secretory granule membrane]
(Caenorhabditis elegans)
Nep7 [secretory granule membrane]
(Drosophila melanogaster)
Nepl19 [secretory granule membrane]
(Drosophila melanogaster)
Nepl20 [secretory granule membrane]
(Drosophila melanogaster)
mme [secretory granule membrane]
(Xenopus tropicalis)
Nepl12 [secretory granule membrane]
(Drosophila melanogaster)
nep-20 [secretory granule membrane]
(Caenorhabditis elegans)
nep-24 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl17 [secretory granule membrane]
(Drosophila melanogaster)
nep-25 [secretory granule membrane]
(Caenorhabditis elegans)
nep-18 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl6 [secretory granule membrane]
(Drosophila melanogaster)
nep-13 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl11 [secretory granule membrane]
(Drosophila melanogaster)
nep-16 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl3 [secretory granule membrane]
(Drosophila melanogaster)
Nepl7 [secretory granule membrane]
(Drosophila melanogaster)
nep-23 [secretory granule membrane]
(Caenorhabditis elegans)
Nep5 [secretory granule membrane]
(Drosophila melanogaster)
Nepl8 [secretory granule membrane]
(Drosophila melanogaster)
nep-12 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl16 [secretory granule membrane]
(Drosophila melanogaster)
nep-17 [secretory granule membrane]
(Caenorhabditis elegans)
nep-6 [secretory granule membrane]
(Caenorhabditis elegans)
nep-22 [secretory granule membrane]
(Caenorhabditis elegans)
nep-3 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl10 [secretory granule membrane]
(Drosophila melanogaster)
Nepl4 [secretory granule membrane]
(Drosophila melanogaster)
Nep6 [secretory granule membrane]
(Drosophila melanogaster)
MME [secretory granule membrane]
(Bos taurus)
MME [secretory granule membrane]
(Caenorhabditis elegans)
MME [secretory granule membrane]
(Canis familiaris)
MME [secretory granule membrane]
(Drosophila melanogaster)
MME [secretory granule membrane]
(Gallus gallus)
MME [secretory granule membrane]
(Mus musculus)
MME [secretory granule membrane]
(Rattus norvegicus)
MME [secretory granule membrane]
(Sus scrofa)
nep-8 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl21 [secretory granule membrane]
(Drosophila melanogaster)
nep-10 [secretory granule membrane]
(Caenorhabditis elegans)
Nepl9 [secretory granule membrane]
(Drosophila melanogaster)
Nepl15 [secretory granule membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011511157.1
,
NP_009218.2
,
XP_006713710.1
,
NP_009220.2
,
XP_011511159.1
,
XP_006713709.1
,
XP_011511158.1
,
NP_009219.2
,
NP_000893.2
ZINC - World Drugs
NEP_HUMAN
Guide to Pharmacology - Targets
1611
OpenTargets
ENSG00000196549
ZINC - Substances
NEP_HUMAN
ZINC - Biogenic
NEP_HUMAN
ZINC target
P08473
PRO
P08473
PDB
2QPJ
,
6XVP
,
1R1H
,
2YB9
,
1R1I
,
6THP
,
6SUK
,
6GID
,
1R1J
,
6SH1
,
4CTH
,
6SH2
,
5JMY
,
1Y8J
,
1DMT
,
6SVY
ZINC - Investigational
NEP_HUMAN
ZINC - Metabolites
NEP_HUMAN
GeneCards
P08473
HPA
ENSG00000196549-MME
Ensembl
ENST00000680057
,
ENSP00000502021
,
ENST00000492661
,
ENSP00000420542
,
ENSP00000418791
,
ENST00000473730
,
ENSP00000505211
,
ENST00000360490
,
ENST00000462745
,
ENST00000680282
,
ENSP00000420389
,
ENSG00000196549
,
ENSP00000353679
,
ENSP00000419653
,
ENST00000675418
,
ENSP00000418525
,
ENST00000491026
,
ENSP00000417079
,
ENSP00000505690
,
ENST00000493237
,
ENST00000460393
Pharos - Targets
P08473
Orphanet
23768
ZINC - Predictions - Purchasable
NEP_HUMAN
HMDB Protein
HMDBP02539
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.537
4
UniProt:Q8WZA1 POMGNT1
6
POMGNT1 P493R [Golgi membrane]
(R-HSA-5617048)
POMGNT1 W475* [Golgi membrane]
(R-HSA-5617097)
POMGNT1 R63* [Golgi membrane]
(R-HSA-5617033)
POMGNT1 R605Vfs*29 [Golgi membrane]
(R-HSA-5617081)
POMGNT1 S550N [Golgi membrane]
(R-HSA-5617094)
POMGNT1 [Golgi membrane]
(R-HSA-5617040)
0.527
2
UniProt:A0PJW6 TMEM223
1
TMEM223 [mitochondrial inner membrane]
(R-HSA-9865797)
0.527
2
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.499
6
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