Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CTSA(29-326) [extracellular region]
Stable Identifier
R-HSA-6806187
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CTSA 32kDa chain, Cathepsin A, Lysosomal protective protein, PPGB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
CTSA(29-326) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10619 CTSA
Gene Names
CTSA, PPGB
Chain
signal peptide:1-28, chain:29-480, chain:29-326, chain:327-480
Reference Genes
BioGPS Gene:5476 CTSA
COSMIC (genes):CTSA CTSA
CTD Gene:5476 CTSA
dbSNP Gene:5476 CTSA
ENSEMBL:ENSG00000064601 CTSA
HGNC:9251 CTSA
KEGG:hsa:5476 CTSA
Monarch:5476 CTSA
NCBI Gene:5476 CTSA
OMIM:613111 CTSA
UCSC:P10619 CTSA
Reference Transcript
RefSeq:NM_001167594.2 CTSA
RefSeq:NM_001127695.2 CTSA
RefSeq:NM_000308.3 CTSA
Other Identifiers
11721499_x_at
11748622_s_at
16914352
200661_3p_at
200661_PM_at
200661_at
3887118
3887119
3887120
3887121
3887122
3887123
3887124
3887125
3887126
3887127
3887128
3887129
3887130
3887131
3887132
3887133
3887134
3887135
3887136
3887137
3887138
3887139
3887140
3887141
3887142
3887143
3887144
3887145
3887146
3887147
3887148
3887149
3887150
3887151
3887152
3887153
3887154
39062_at
5476
8063078
A_14_P119540
A_14_P135478
A_24_P74371
A_24_P74374
A_33_P3280213
GE56050
GE85531
GO:0003824
GO:0004180
GO:0004185
GO:0005576
GO:0005764
GO:0005773
GO:0005783
GO:0006508
GO:0006886
GO:0008047
GO:0016020
GO:0016787
GO:0031647
GO:0035578
GO:0043202
GO:0043226
GO:0043231
GO:0070062
GO:0098575
GO:0098772
GO:0140096
GO:1904714
GO:1904715
HMNXSV003021606
ILMN_1719286
M22960_at
PH_hs_0006486
TC20000361.hg
g4505988_3p_s_at
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CTSA(327-480) [azurophil granule lumen]
CTSA(29-326) [azurophil granule lumen]
CTSA(327-480) [extracellular region]
CTSA(327-480) [lysosomal lumen]
CTSA(29-326) [lysosomal lumen]
CTSA(29-480) [lysosomal lumen]
Inferred To
CTSA(29-326) [extracellular region]
(Caenorhabditis elegans)
CTSA(29-326) [extracellular region]
(Gallus gallus)
CTSA [extracellular region]
(Bos taurus)
CTSA [extracellular region]
(Canis familiaris)
CTSA [extracellular region]
(Sus scrofa)
ctsa-1.1 [extracellular region]
(Caenorhabditis elegans)
ctsa-2 [extracellular region]
(Caenorhabditis elegans)
ctsa-1.2 [extracellular region]
(Caenorhabditis elegans)
ctsa-3.1 [extracellular region]
(Caenorhabditis elegans)
ctsa-3.2 [extracellular region]
(Caenorhabditis elegans)
Ctsa [extracellular region]
(Mus musculus)
Ctsa [extracellular region]
(Rattus norvegicus)
ctsa [extracellular region]
(Danio rerio)
ctsa [extracellular region]
(Xenopus tropicalis)
Homologues of CTSA(29-326) [extracellular region]
(Caenorhabditis elegans)
ctsa-4.2 [extracellular region]
(Caenorhabditis elegans)
ctsa-4.1 [extracellular region]
(Caenorhabditis elegans)
Cross References
ZINC - World Drugs
PPGB_HUMAN
Guide to Pharmacology - Targets
1581
OpenTargets
ENSG00000064601
ENSEMBL
ENSP00000493613
,
ENSP00000346952
,
ENST00000191018
,
ENST00000372459
,
ENST00000607482
,
ENST00000646241
,
ENSP00000361537
,
ENSP00000191018
,
ENST00000354880
,
ENSP00000475524
ZINC - FDA approved
PPGB_HUMAN
ZINC - Substances
PPGB_HUMAN
ZINC target
P10619
PRO
P10619
GlyGen
P10619
PDB
3BP7
,
4MWT
,
4AZ3
,
1IVY
,
4MWS
,
6WIA
,
3BXN
,
3BP4
,
4CIB
,
4AZ0
,
4CIA
,
4CI9
HPA
ENSG00000064601-CTSA
Pharos - Targets
P10619
Orphanet
CTSA
ZINC - Predictions - Purchasable
PPGB_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.643
4
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text