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SERPINB3 [extracellular region]
Stable Identifier
R-HSA-6806189
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Serpin B3, SPB3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
SERPINB3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29508 SERPINB3
Gene Names
SERPINB3, SCCA, SCCA1
Chain
chain:1-390
Reference Genes
BioGPS Gene:6317 SERPINB3
COSMIC (genes):SERPINB3 SERPINB3
CTD Gene:6317 SERPINB3
dbSNP Gene:6317 SERPINB3
ENSEMBL:ENSG00000057149 SERPINB3
ENSEMBL_homo_sapiens_GENE:ENSG00000057149.16 SERPINB3
HGNC:10569 SERPINB3
KEGG Gene (Homo sapiens):6317 SERPINB3
Monarch:6317 SERPINB3
NCBI Gene:6317 SERPINB3
OMIM:600517 SERPINB3
UCSC:P29508 SERPINB3
Reference Transcript
RefSeq:NM_006919.2 SERPINB3
Other Identifiers
11729692_a_at
11729693_at
11729694_s_at
11752804_a_at
11752805_s_at
11752806_x_at
11753202_s_at
1343_s_at
16855723
209719_PM_x_at
209719_x_at
209720_PM_s_at
209720_s_at
3811577
3811584
3811585
3811590
3811597
3811598
3811599
3811600
3811601
3811602
3811603
3811608
3811609
3811610
3811612
3811613
3811614
6317
8023696
A_23_P55632
GE79177
GO:0001618
GO:0002020
GO:0004867
GO:0004869
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0008284
GO:0010466
GO:0010718
GO:0010950
GO:0010951
GO:0023052
GO:0030154
GO:0030335
GO:0030414
GO:0031410
GO:0031982
GO:0035425
GO:0035578
GO:0036211
GO:0038001
GO:0043086
GO:0043226
GO:0043508
GO:0045861
GO:0046718
GO:0048856
GO:0048870
GO:0070062
GO:0098772
HMNXSV003016436
ILMN_1703855
ILMN_2120222
PH_hs_0032236
S66896_at
TC18001005.hg
g1276435_3p_s_at
g13528851_3p_s_at
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
SERPINB3 [azurophil granule lumen]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
LOC110261636 [extracellular region]
(Sus scrofa)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
Spn27A [extracellular region]
(Drosophila melanogaster)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
LOC100153783 [extracellular region]
(Sus scrofa)
Serpinb3b [extracellular region]
(Mus musculus)
srp-8 [extracellular region]
(Caenorhabditis elegans)
LOC107131803 [extracellular region]
(Bos taurus)
srp-7 [extracellular region]
(Caenorhabditis elegans)
LOC110261633 [extracellular region]
(Sus scrofa)
Spn42Db [extracellular region]
(Drosophila melanogaster)
SERPINB3 [extracellular region]
(Bos taurus)
SERPINB3 [extracellular region]
(Caenorhabditis elegans)
SERPINB3 [extracellular region]
(Canis familiaris)
SERPINB3 [extracellular region]
(Gallus gallus)
serpinb1 [extracellular region]
(Danio rerio)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
Serpinb3 [extracellular region]
(Rattus norvegicus)
Spn38F [extracellular region]
(Drosophila melanogaster)
srp-3 [extracellular region]
(Caenorhabditis elegans)
LOC110261637 [extracellular region]
(Sus scrofa)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
Homologues of SERPINB3 [extracellular region]
(Bos taurus)
Homologues of SERPINB3 [extracellular region]
(Caenorhabditis elegans)
Homologues of SERPINB3 [extracellular region]
(Danio rerio)
Homologues of SERPINB3 [extracellular region]
(Drosophila melanogaster)
Homologues of SERPINB3 [extracellular region]
(Gallus gallus)
Homologues of SERPINB3 [extracellular region]
(Mus musculus)
Homologues of SERPINB3 [extracellular region]
(Sus scrofa)
Serpinb3c [extracellular region]
(Mus musculus)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
serpinb4 [extracellular region]
(Xenopus tropicalis)
Serpinb3d [extracellular region]
(Mus musculus)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Acp76A [extracellular region]
(Drosophila melanogaster)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
Spn75F [extracellular region]
(Drosophila melanogaster)
LOC786410 [extracellular region]
(Bos taurus)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
nec [extracellular region]
(Drosophila melanogaster)
serpinb1l2 [extracellular region]
(Danio rerio)
Spn31A [extracellular region]
(Drosophila melanogaster)
LOC519132 [extracellular region]
(Bos taurus)
LOC522479 [extracellular region]
(Bos taurus)
srp-1 [extracellular region]
(Caenorhabditis elegans)
LOC511695 [extracellular region]
(Bos taurus)
Serpinb3a [extracellular region]
(Mus musculus)
Spn42De [extracellular region]
(Drosophila melanogaster)
Spn85F [extracellular region]
(Drosophila melanogaster)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_008850.1
OpenTargets
ENSG00000057149
GeneCards
P29508
HPA
ENSG00000057149-SERPINB3
Ensembl
ENSP00000329498
,
ENSG00000057149
,
ENST00000332821
,
ENST00000283752
,
ENSP00000283752
PRO
P29508
Pharos - Targets
P29508
PDB
4ZK3
,
4ZK0
,
2ZV6
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14330 GPR18
1
GPR18 [plasma membrane]
(R-HSA-517529)
0.527
2
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.527
2
UniProt:P01160 NPPA
5
NPPA(124-151) [extracellular region]
(R-HSA-5578799)
NPPA(1-151) [extracellular region]
(R-HSA-976950)
NPPA(1-25) [extracellular region]
(R-HSA-5578791)
NPPA(56-123) [extracellular region]
(R-HSA-5578797)
NPPA(26-55) [extracellular region]
(R-HSA-5578794)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
3
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