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HEXB(122-311) [extracellular region]
Stable Identifier
R-HSA-6806190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
HEXBB, Beta-hexosaminidase subunit beta B, HEXB_HUMAN, HEXB
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
HEXB(122-311) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07686 HEXB
Gene Names
HEXB, HCC7
Chain
signal peptide:1-42, propeptide:43-121, chain:122-556, chain:122-311, chain:315-556
Reference Genes
BioGPS Gene:3074 HEXB
COSMIC (genes):HEXB HEXB
CTD Gene:3074 HEXB
dbSNP Gene:3074 HEXB
ENSEMBL:ENSG00000049860 HEXB
HGNC:4879 HEXB
KEGG:hsa:3074 HEXB
Monarch:3074 HEXB
NCBI Gene:3074 HEXB
OMIM:606873 HEXB
UCSC:P07686 HEXB
Reference Transcript
RefSeq:NM_001292004.1 HEXB
RefSeq:NM_000521.3 HEXB
Other Identifiers
11715837_a_at
16986203
201944_PM_at
201944_at
2815794
2815795
2815796
2815797
2815798
2815799
2815804
2815805
2815806
2815807
2815808
2815810
2815811
2815812
2815814
2815815
2815816
2815817
2815820
2815821
2815822
2815823
2815824
2815825
2815826
2815827
2815828
2815829
2815830
2815832
2815833
2815834
2815835
2815836
2815837
2815839
2815840
2815841
2815842
2815843
2815844
2815845
3074
34888_at
57929_at
64507_at
8106252
A_14_P100715
A_14_P119296
A_23_P156049
GE60505
GO:0001501
GO:0001669
GO:0003824
GO:0004553
GO:0004563
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005975
GO:0006355
GO:0006629
GO:0006687
GO:0006689
GO:0006790
GO:0006874
GO:0007040
GO:0007338
GO:0007341
GO:0007605
GO:0007626
GO:0008049
GO:0008360
GO:0008375
GO:0008654
GO:0009313
GO:0015929
GO:0016020
GO:0016740
GO:0016787
GO:0016798
GO:0019915
GO:0019953
GO:0022414
GO:0030203
GO:0030207
GO:0030209
GO:0030214
GO:0031410
GO:0035578
GO:0042552
GO:0042582
GO:0042802
GO:0043202
GO:0043226
GO:0043615
GO:0045944
GO:0048477
GO:0048856
GO:0048870
GO:0050877
GO:0050885
GO:0050905
GO:0051651
GO:0060473
GO:0070050
GO:0070062
GO:0102148
GO:1901135
GO:1905379
HMNXSV003058045
ILMN_1806692
M23294_at
PH_hs_0022175
TC05000359.hg
TC05002451.hg
g13128866_3p_s_at
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
HEXB S62L [lysosomal lumen]
HEXB R284* [lysosomal lumen]
HEXB M26Cfs*5 [lysosomal lumen]
HEXB I322Kfs*5 [lysosomal lumen]
HEXB(316-556) [lysosomal lumen]
HEXB(122-311) [azurophil granule lumen]
HEXB(315-556) [azurophil granule lumen]
HEXB(315-556) [extracellular region]
HEXB(50-107) [lysosomal lumen]
HEXB(122-311) [lysosomal lumen]
Inferred To
Hexo2 [extracellular region]
(Drosophila melanogaster)
hexb [extracellular region]
(Xenopus tropicalis)
Hexo1 [extracellular region]
(Drosophila melanogaster)
Homologues of HEXB(122-311) [extracellular region]
(Drosophila melanogaster)
hexb2 [extracellular region]
(Dictyostelium discoideum)
HEXB(122-311) [extracellular region]
(Bos taurus)
HEXB [extracellular region]
(Canis familiaris)
HEXB [extracellular region]
(Gallus gallus)
HEXB [extracellular region]
(Sus scrofa)
fdl [extracellular region]
(Drosophila melanogaster)
Hexb [extracellular region]
(Mus musculus)
Hexb [extracellular region]
(Rattus norvegicus)
hex-1 [extracellular region]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000049860
ENSEMBL
ENSP00000261416
,
ENST00000261416
HPA
ENSG00000049860-HEXB
ZINC - Substances
HEXB_HUMAN
ZINC target
P07686
PRO
P07686
Pharos - Targets
P07686
GlyGen
P07686
Orphanet
HEXB
ZINC - Predictions - Purchasable
HEXB_HUMAN
HMDB Protein
HMDBP00871
PDB
2GK1
,
1O7A
,
1NP0
,
1NOU
,
2GJX
,
5BRO
,
1NOW
,
3LMY
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06865 HEXA
3
HEXA(23-73) [lysosomal lumen]
(R-HSA-9842401)
HEXA(88-528) [lysosomal lumen]
(R-HSA-1605799)
HEXA Y427Ifs*5 [lysosomal lumen]
(R-HSA-3700918)
0.734
5
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.527
2
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