Reactome | PSMD1 [extracellular region]

PSMD1 [extracellular region]

Stable Identifier

R-HSA-6806194

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

26S proteasome non-ATPase regulatory subunit 1, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112, RPN2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99460 PSMD1

Gene Names

PSMD1

Chain

chain:1-953

Reference Genes

BioGPS Gene:5707 PSMD1

COSMIC (genes):PSMD1 PSMD1

CTD Gene:5707 PSMD1

dbSNP Gene:5707 PSMD1

ENSEMBL:ENSG00000173692 PSMD1

HGNC:9554 PSMD1

KEGG:hsa:5707 PSMD1

Monarch:5707 PSMD1

NCBI Gene:5707 PSMD1

OMIM:617842 PSMD1

UCSC:Q99460 PSMD1

Reference Transcript

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

PSMD1 [cytosol]

PSMD1 [nucleoplasm]

PSMD1 [azurophil granule lumen]

Inferred To

PSMD1 [extracellular region] (Bos taurus)

PSMD1 [extracellular region] (Canis familiaris)

PSMD1 [extracellular region] (Gallus gallus)

PSMD1 [extracellular region] (Plasmodium falciparum)

PSMD1 [extracellular region] (Sus scrofa)

rpn-2 [extracellular region] (Caenorhabditis elegans)

rpn2 [extracellular region] (Schizosaccharomyces pombe)

psmd1 [extracellular region] (Danio rerio)

psmd1 [extracellular region] (Xenopus tropicalis)

Psmd1 [extracellular region] (Mus musculus)

Psmd1 [extracellular region] (Rattus norvegicus)

Rpn2 [extracellular region] (Drosophila melanogaster)

RPN2 [extracellular region] (Saccharomyces cerevisiae)

psmD1 [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002798.2, NP_001177966.1

OpenTargets

ENSG00000173692

ENSEMBL

ENSP00000309474, ENSP00000503068, ENST00000677230, ENST00000308696, ENST00000373635, ENSG00000173692, ENSP00000362738

HPA

ENSG00000173692-PSMD1

GeneCards

PSMD1

PRO

Q99460

Pharos - Targets

Q99460

GlyGen

Q99460

PDB

5T0H, 7W37, 5GJR, 5VGZ, 9E8L, 9E8N, 5VFP, 6WJN, 6MSG, 7QXX, 7W3C, 7QY7, 8K0G, 7W3F, 7QYA, 9E8G, 5VHS, 5T0I, 8JTI, 9E8K, 5V1Y, 9E8I, 5T0C, 5L4K, 8USC, 8JRT, 5VFS, 7W3B, 6MSJ, 9E8Q, 7W3A, 7W3I, 7QXU, 7W39, 5VFQ, 8USD, 6MSB, 7W3G, 6WJD, 6UYJ, 5GJQ, 5T0G, 5LN3, 9E8O, 7QXW, 8JRI, 6MSE, 7QXN, 7QXP, 7W3M, 6MSD, 7W3K, 6OI4, 7QYB, 5VHH, 5T0J, 5M32, 8CVT, 5VHI, 6CO4, 5V1Z, 9E8J, 9E8H, 8USB, 5VHF, 7W3J, 7W3H, 6MSK, 5VFT, 6MSH, 7W38, 5VFU, 5VFR, 6UYI

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.802	5
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.802	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.758	12
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.75	7
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.669	4
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.669	4
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	4
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.643	3
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.564	2
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	2
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.553	2
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.528	2
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.527	3
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	3
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	2
UniProt:Q5JXX7 TMM31			0.527	3
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12