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DYNC1H1 [extracellular region]
Stable Identifier
R-HSA-6806223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
cytoplasmic dynein 1 heavy chain 1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
DYNC1H1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14204 DYNC1H1
Gene Names
DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325
Chain
initiator methionine:, chain:2-4646
Reference Genes
BioGPS Gene:1778 DYNC1H1
COSMIC (genes):DYNC1H1 DYNC1H1
CTD Gene:1778 DYNC1H1
dbSNP Gene:1778 DYNC1H1
ENSEMBL:ENSG00000197102 DYNC1H1
ENSEMBL_homo_sapiens_GENE:ENSG00000197102.14 DYNC1H1
HGNC:2961 DYNC1H1
KEGG Gene (Homo sapiens):1778 DYNC1H1
Monarch:1778 DYNC1H1
NCBI Gene:1778 DYNC1H1
OMIM:600112 DYNC1H1
UCSC:Q14204 DYNC1H1
Reference Transcript
RefSeq:NM_001376.4 DYNC1H1
Other Identifiers
11715589_at
11715590_at
11715591_s_at
11715592_x_at
16788883
1778
211928_PM_at
211928_at
229115_PM_at
229115_at
241084_PM_x_at
241084_x_at
244768_PM_at
244768_at
3107195
3552855
3552861
3552862
3552863
3552864
3552865
3552866
3552867
3552868
3552869
3552870
3552872
3552873
3552874
3552875
3552876
3552877
3552878
3552880
3552881
3552882
3552884
3552885
3552886
3552888
3552889
3552890
3552892
3552893
3552894
3552896
3552897
3552899
3552900
3552901
3552903
3552904
3552906
3552907
3552908
3552909
3552910
3552912
3552913
3552914
3552915
3552919
3552922
3552923
3552924
3552925
3552926
3552928
3552929
3552930
3552932
3552933
3552934
3552936
3552937
3552938
3552941
3552945
3552946
3552947
3552948
3552950
3552951
3552952
3552953
3552954
3552955
3552956
3552957
3552958
3552959
3552962
3552964
3552966
3552969
3552970
3552971
3552974
3552975
3552976
3552977
3552978
3552979
3552980
3552981
3552982
3552996
3552997
3552999
37300_at
50084_at
7976876
A_14_P118619
GE53058
GO:0000166
GO:0000278
GO:0003723
GO:0003774
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005773
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005868
GO:0005874
GO:0005881
GO:0005938
GO:0007010
GO:0007018
GO:0007049
GO:0007052
GO:0007059
GO:0007097
GO:0008090
GO:0008569
GO:0016020
GO:0016787
GO:0016887
GO:0030175
GO:0030286
GO:0031122
GO:0031410
GO:0032388
GO:0033962
GO:0034063
GO:0035578
GO:0043226
GO:0045505
GO:0051293
GO:0051301
GO:0051959
GO:0060236
GO:0070062
GO:0090235
GO:0120162
GO:0140657
GO:1904115
GO:1905832
HMNXSV003036130
Hs.302653.0.S1_3p_at
Hs.309947.0.A1_3p_s_at
Hs.7720.0.A1_3p_at
Hs.7720.3.A1_3p_at
PH_hs_0000792
TC14000777.hg
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
DYNC1H1 [azurophil granule lumen]
DYNC1H1 [cytosol]
Inferred To
DYNC1H1 [extracellular region]
(Bos taurus)
DYNC1H1 [extracellular region]
(Caenorhabditis elegans)
DYNC1H1 [extracellular region]
(Canis familiaris)
DYNC1H1 [extracellular region]
(Dictyostelium discoideum)
DYNC1H1 [extracellular region]
(Drosophila melanogaster)
DYNC1H1 [extracellular region]
(Gallus gallus)
DYNC1H1 [extracellular region]
(Mus musculus)
DYNC1H1 [extracellular region]
(Plasmodium falciparum)
DYNC1H1 [extracellular region]
(Rattus norvegicus)
DYNC1H1 [extracellular region]
(Saccharomyces cerevisiae)
DYNC1H1 [extracellular region]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001367.2
OpenTargets
ENSG00000197102
GeneCards
Q14204
HPA
ENSG00000197102-DYNC1H1
Ensembl
ENSG00000197102
,
ENST00000360184
,
ENSP00000348965
PRO
Q14204
Pharos - Targets
Q14204
Orphanet
20586
PDB
8PQV
,
7Z8L
,
8PR1
,
8FDT
,
6F3A
,
6F1V
,
7Z8H
,
8PTK
,
6F1Y
,
8PQZ
,
7Z8K
,
6F38
,
6F1T
,
8PR0
,
7Z8G
,
6F1U
,
7Z8J
,
8PQY
,
8DYU
,
5NUG
,
8FD6
,
8DYV
,
7Z8F
,
8PR3
,
5OWO
,
8FCY
,
7Z8I
,
8PQW
,
8FDU
,
8PR2
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.766
8
UniProt:P43034 PAFAH1B1
1
PAFAH1B1 [cytosol]
(R-HSA-376249)
0.725
4
UniProt:Q14203 DCTN1
7
DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711969)
DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711960)
DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9701997)
DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711959)
DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711953)
DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711962)
DCTN1 [cytosol]
(R-HSA-535580)
0.615
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
20
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q7L5A8 FA2H
1
FA2H [endoplasmic reticulum membrane]
(R-HSA-5693771)
0.556
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.499
2
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