Reactome | CTSA(327-480) [extracellular region]

CTSA(327-480) [extracellular region]

Stable Identifier

R-HSA-6806233

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CTSA 20kDa chain, Cathepsin A, Lysosomal protective protein, PPGB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10619 CTSA

Gene Names

CTSA, PPGB

Chain

signal peptide:1-28, chain:29-480, chain:29-326, chain:327-480

Reference Genes

BioGPS Gene:5476 CTSA

COSMIC (genes):CTSA CTSA

CTD Gene:5476 CTSA

dbSNP Gene:5476 CTSA

ENSEMBL:ENSG00000064601 CTSA

ENSEMBL_homo_sapiens_GENE:ENSG00000064601.21 CTSA

HGNC:9251 CTSA

KEGG Gene (Homo sapiens):5476 CTSA

Monarch:5476 CTSA

NCBI Gene:5476 CTSA

OMIM:613111 CTSA

UCSC:P10619 CTSA

Reference Transcript

Other Identifiers

11721499_x_at

11748622_s_at

16914352

200661_3p_at

200661_PM_at

200661_at

3887121

3887122

3887123

3887124

3887126

3887127

3887128

3887129

3887130

3887132

3887135

3887137

3887138

3887140

3887141

3887144

3887146

3887149

3887152

3887153

3887154

39062_at

5476

8063078

A_24_P74371

A_24_P74374

A_33_P3280213

GE56050

GO:0003824

GO:0004180

GO:0004185

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0006508

GO:0006886

GO:0006914

GO:0008047

GO:0008233

GO:0016020

GO:0016787

GO:0030163

GO:0031410

GO:0031647

GO:0035578

GO:0043202

GO:0043226

GO:0043231

GO:0070062

GO:0098575

GO:0098772

GO:0140096

GO:1904714

GO:1904715

HMNXSV003021606

ILMN_1719286

M22960_at

PH_hs_0006486

TC20000361.hg

g4505988_3p_s_at

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

CTSA(29-480) [lysosomal lumen]

CTSA(29-326) [extracellular region]

CTSA(29-326) [azurophil granule lumen]

CTSA(327-480) [azurophil granule lumen]

CTSA(29-326) [lysosomal lumen]

CTSA(327-480) [lysosomal lumen]

Inferred To

CTSA [extracellular region] (Bos taurus)

CTSA [extracellular region] (Canis familiaris)

CTSA [extracellular region] (Sus scrofa)

Homologues of CTSA(327-480) [extracellular region] (Caenorhabditis elegans)

ctsa-1.1 [extracellular region] (Caenorhabditis elegans)

ctsa-2 [extracellular region] (Caenorhabditis elegans)

ctsa-1.2 [extracellular region] (Caenorhabditis elegans)

ctsa-3.1 [extracellular region] (Caenorhabditis elegans)

ctsa-3.2 [extracellular region] (Caenorhabditis elegans)

Ctsa [extracellular region] (Mus musculus)

Ctsa [extracellular region] (Rattus norvegicus)

ctsa [extracellular region] (Danio rerio)

ctsa [extracellular region] (Xenopus tropicalis)

ctsa-4.2 [extracellular region] (Caenorhabditis elegans)

CTSA(327-480) [extracellular region] (Caenorhabditis elegans)

CTSA(327-480) [extracellular region] (Gallus gallus)

ctsa-4.1 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001161066.1, NP_001121167.1, NP_000299.2

ZINC - World Drugs

PPGB_HUMAN

Guide to Pharmacology - Targets

1581

OpenTargets

ENSG00000064601

ZINC - FDA approved

PPGB_HUMAN

ZINC - Substances

PPGB_HUMAN

ZINC target

P10619

PRO

P10619

PDB

4AZ0, 4AZ3, 3BXN, 3BP7, 4MWT, 4MWS, 1IVY, 6WIA, 4CI9, 3BP4, 4CIB, 4CIA

HPA

ENSG00000064601-CTSA

GeneCards

P10619

Ensembl

ENSG00000064601, ENSP00000475524, ENST00000191018, ENST00000646241, ENST00000372459, ENSP00000493613, ENSP00000346952, ENST00000607482, ENST00000354880, ENSP00000191018, ENSP00000361537

Pharos - Targets

P10619

ZINC - Predictions - Purchasable

PPGB_HUMAN

Orphanet

15821

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.643	4
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.508	2

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