Reactome | PGRMC1 [plasma membrane]

PGRMC1 [plasma membrane]

Stable Identifier

R-HSA-6806314

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Membrane-associated progesterone receptor component 1, PGRC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00264 PGRMC1

Gene Names

PGRMC1, HPR6.6, PGRMC

Chain

chain:1-195

Reference Genes

BioGPS Gene:10857 PGRMC1

COSMIC (genes):PGRMC1 PGRMC1

CTD Gene:10857 PGRMC1

dbSNP Gene:10857 PGRMC1

ENSEMBL:ENSG00000101856 PGRMC1

HGNC:16090 PGRMC1

KEGG:hsa:10857 PGRMC1

Monarch:10857 PGRMC1

NCBI Gene:10857 PGRMC1

OMIM:300435 PGRMC1

UCSC:O00264 PGRMC1

Reference Transcript

Other Identifiers

10857

11715488_s_at

11715489_a_at

17106546

201120_PM_s_at

201120_s_at

201121_PM_s_at

201121_s_at

38802_at

3988741

3988742

3988744

3988746

3988747

3988748

3988749

8169617

A_23_P114275

A_33_P3332130

GE62032

GO:0001540

GO:0005496

GO:0005515

GO:0005576

GO:0005739

GO:0005741

GO:0005783

GO:0005789

GO:0005886

GO:0006783

GO:0008289

GO:0012505

GO:0016020

GO:0020037

GO:0030868

GO:0035579

GO:0042803

GO:0043005

GO:0043025

GO:0043226

GO:0044297

GO:0045202

GO:0046872

GO:0140077

GO:1903078

HMNXSV003032555

Hs.90061.0.S1_3p_a_at

ILMN_1684771

PH_hs_0005032

TC0X000580.hg

Y12711_at

g6857798_3p_a_at

Participates

as a member of

Specific granule membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

PGRMC1 [specific granule membrane]

Inferred To

pgrmc1 [plasma membrane] (Danio rerio)

pgrmc1 [plasma membrane] (Xenopus tropicalis)

vem-1 [plasma membrane] (Caenorhabditis elegans)

PGRMC1 [plasma membrane] (Bos taurus)

PGRMC1 [plasma membrane] (Canis familiaris)

PGRMC1 [plasma membrane] (Dictyostelium discoideum)

PGRMC1 [plasma membrane] (Gallus gallus)

PGRMC1 [plasma membrane] (Mus musculus)

PGRMC1 [plasma membrane] (Rattus norvegicus)

PGRMC1 [plasma membrane] (Schizosaccharomyces pombe)

PGRMC1 [plasma membrane] (Sus scrofa)

MSBP [plasma membrane] (Drosophila melanogaster)

DAP1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000442821, ENST00000535419, ENSP00000217971, ENST00000217971

OpenTargets

ENSG00000101856

HPA

ENSG00000101856-PGRMC1

PRO

O00264

Pharos - Targets

O00264

GlyGen

O00264

Orphanet

PGRMC1

HMDB Protein

HMDBP08664

PDB

4X8Y

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16435 POR	1	POR [endoplasmic reticulum membrane] (R-HSA-59988)	0.682	6
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.666	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.564	2
UniProt:P05177 CYP1A2	1	CYP1A2 [endoplasmic reticulum membrane] (R-HSA-52625)	0.527	3
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.527	2
UniProt:P08684 CYP3A4	1	CYP3A4 [endoplasmic reticulum membrane] (R-HSA-52639)	0.463	2
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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