Reactome | DNASE1L1 [extracellular region]

DNASE1L1 [extracellular region]

Stable Identifier

R-HSA-6806320

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Deoxyribonuclease-1-like 1 ecNumber3.1.21.-/ecNumber, DNSL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49184 DNASE1L1

Gene Names

DNASE1L1, DNAS1L1, DNL1L

Chain

signal peptide:1-18, chain:19-302

Reference Genes

BioGPS Gene:1774 DNASE1L1

COSMIC (genes):DNASE1L1 DNASE1L1

CTD Gene:1774 DNASE1L1

dbSNP Gene:1774 DNASE1L1

ENSEMBL:ENSG00000013563 DNASE1L1

ENSEMBL_homo_sapiens_GENE:ENSG00000013563.14 DNASE1L1

HGNC:2957 DNASE1L1

KEGG Gene (Homo sapiens):1774 DNASE1L1

Monarch:1774 DNASE1L1

NCBI Gene:1774 DNASE1L1

OMIM:300081 DNASE1L1

UCSC:P49184 DNASE1L1

Reference Transcript

Other Identifiers

11741203_a_at

11755208_a_at

17115571

1774

203912_PM_s_at

203912_s_at

2886166

37213_at

37214_g_at

3821801

4027297

4027298

4027299

4027301

4027303

4027304

4027305

4027306

4027308

4027309

4027311

4027312

4027313

4027314

4027315

4027317

4027318

4027320

4027321

4027323

78701_at

8176076

A_23_P85164

A_32_P161166

GE60127

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0004530

GO:0004536

GO:0005515

GO:0005576

GO:0005634

GO:0005783

GO:0006259

GO:0006308

GO:0016787

GO:0031410

GO:0035580

GO:0043226

GO:0140097

HMNXSV003000427

HMNXSV003011836

HMNXSV003048908

ILMN_1681695

ILMN_1801230

ILMN_2256081

ILMN_2380967

L44140_cds4_s_at

PH_hs_0004445

TC0X001532.hg

X90392_at

g5803006_3p_a_at

p33947

Participates

as a member of

Specific granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

DNASE1L1 [specific granule lumen]

Inferred To

Dnase1l1 [extracellular region] (Mus musculus)

Dnase1l1 [extracellular region] (Rattus norvegicus)

LOC116406574 [extracellular region] (Xenopus tropicalis)

DNASE1L1 [extracellular region] (Bos taurus)

DNASE1L1 [extracellular region] (Canis familiaris)

DNASE1L1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001009932.1, XP_005277886.1, XP_016884821.1, NP_001009934.1, XP_011529424.1, NP_001009933.1, NP_006721.1, NP_001290549.1

OpenTargets

ENSG00000013563

HPA

ENSG00000013563-DNASE1L1

GeneCards

P49184

Ensembl

ENSG00000013563, ENSP00000358824, ENSP00000377255, ENSP00000014935, ENSP00000309168, ENSP00000358823, ENSP00000358822, ENST00000393638, ENST00000014935, ENST00000369807, ENST00000369808, ENST00000369809, ENST00000309585

PRO

P49184

Pharos - Targets

P49184

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.564	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3

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