Reactome | CRYAB [nucleoplasm]

CRYAB [nucleoplasm]

Stable Identifier

R-HSA-6806336

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Alpha-crystallin B chain, HSPB5, CRYA2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - HSF1-dependent transactivation (Homo sapiens)
      - HSF1-mediated gene expression (Homo sapiens)
        
        Heat shock inducible proteins [nucleoplasm] (Homo sapiens)
        
        CRYAB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02511 CRYAB

Gene Names

CRYAB, CRYA2, HSPB5

Chain

chain:1-175

Reference Genes

BioGPS Gene:1410 CRYAB

COSMIC (genes):CRYAB CRYAB

CTD Gene:1410 CRYAB

dbSNP Gene:1410 CRYAB

ENSEMBL:ENSG00000109846 CRYAB

ENSEMBL_homo_sapiens_GENE:ENSG00000109846.9 CRYAB

HGNC:2389 CRYAB

KEGG Gene (Homo sapiens):1410 CRYAB

Monarch:1410 CRYAB

NCBI Gene:1410 CRYAB

OMIM:123590 CRYAB

Reference Transcript

Other Identifiers

11715620_a_at

1410

16744370

209283_PM_at

209283_at

32242_at

32243_g_at

3391169

3391170

3391171

3391172

3391173

3391176

3391181

3391182

3391183

3391185

7951662

A_24_P206776

GE61321

GE79021

GO:0001540

GO:0001666

GO:0002088

GO:0003012

GO:0005198

GO:0005212

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006457

GO:0006936

GO:0007010

GO:0007021

GO:0007517

GO:0008017

GO:0008092

GO:0009408

GO:0009986

GO:0010629

GO:0012501

GO:0023052

GO:0030018

GO:0030308

GO:0030424

GO:0031109

GO:0031333

GO:0031430

GO:0031674

GO:0032355

GO:0032387

GO:0032432

GO:0032991

GO:0042026

GO:0042542

GO:0042802

GO:0042803

GO:0043010

GO:0043066

GO:0043067

GO:0043197

GO:0043204

GO:0043226

GO:0043292

GO:0044877

GO:0045892

GO:0046872

GO:0048856

GO:0050821

GO:0051082

GO:0051403

GO:0060561

GO:0065003

GO:0070062

GO:0071480

GO:0097060

GO:0097512

GO:1905907

GO:2000378

HMNXSV003033925

ILMN_1729216

S45630_at

TC11002289.hg

g3192942_3p_at

Participates

as a member of

Heat shock inducible proteins [nucleoplasm] (Homo sapiens)

Inferred To

l(2)efl [nucleoplasm] (Drosophila melanogaster)

hsp-12.2 [nucleoplasm] (Caenorhabditis elegans)

CRYAB [nucleoplasm] (Bos taurus)

CRYAB [nucleoplasm] (Canis familiaris)

CRYAB [nucleoplasm] (Gallus gallus)

CRYAB [nucleoplasm] (Mus musculus)

CRYAB [nucleoplasm] (Rattus norvegicus)

CRYAB [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001276736.1, XP_011540910.1, NP_001276737.1, NP_001876.1

OpenTargets

ENSG00000109846

GeneCards

P02511

HPA

ENSG00000109846-CRYAB

Ensembl

ENST00000533879, ENSP00000498735, ENST00000650687, ENSG00000109846, ENSP00000433560, ENST00000527950, ENSP00000436089, ENST00000531198, ENSP00000483554, ENSP00000437149, ENSP00000434247, ENST00000651164, ENST00000527899, ENSP00000435931, ENST00000526180, ENST00000616970, ENSP00000227251, ENST00000227251, ENSP00000499082, ENST00000533475, ENSP00000436051

PRO

P02511

Pharos - Targets

P02511

Orphanet

15805

PDB

4M5T, 3SGR, 3SGN, 2Y22, 7ROJ, 3SGP, 4M5S, 3L1G, 2Y1Z, 6BP9, 2YGD, 3J07, 2WJ7, 5VVV, 3SGM, 2KLR, 2Y1Y, 3SGS, 3SGO, 2N0K

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.876	8
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.709	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	7
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.524	2

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