Reactome | PSMD2 [extracellular region]

PSMD2 [extracellular region]

Stable Identifier

R-HSA-6806479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Tumor necrosis factor type 1 receptor associated protein 2, 55.11 protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13200 PSMD2

Gene Names

PSMD2, TRAP2

Chain

chain:1-908

Reference Genes

BioGPS Gene:5708 PSMD2

COSMIC (genes):PSMD2 PSMD2

CTD Gene:5708 PSMD2

dbSNP Gene:5708 PSMD2

ENSEMBL:ENSG00000175166 PSMD2

HGNC:9559 PSMD2

KEGG:hsa:5708 PSMD2

Monarch:5708 PSMD2

NCBI Gene:5708 PSMD2

OMIM:606223 PSMD2

UCSC:Q13200 PSMD2

Reference Transcript

Other Identifiers

1166_at

11715565_at

11758266_s_at

11758702_s_at

16948871

200830_PM_at

200830_at

2463105

2463107

2463110

2463111

2463113

2463117

2463118

2463119

2463120

2463127

2463128

2655652

2655653

2655654

2655655

2655656

2655657

2655658

2655659

2655660

2655661

2655662

2655663

2655664

2655665

2655666

2655667

2655668

2655669

2655670

2655671

2655672

2655673

2655674

2655675

2655677

2655678

2655679

2655680

2655681

2655682

2655683

2655684

2655685

2655686

2655687

5708

67421_at

8084423

A_14_P109016

A_14_P110634

A_14_P138534

A_24_P42681

A_33_P3373469

D78151_at

GE57295

GE58933

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0008540

GO:0016020

GO:0022624

GO:0030163

GO:0030234

GO:0034515

GO:0034774

GO:0042176

GO:0043161

GO:0043226

GO:0070062

GO:0098772

GO:1904813

HMNXSV003047036

ILMN_1712432

PH_hs_0030008

TC03000999.hg

g4506226_3p_at

Participates

as a member of

Other forms of this molecule

PSMD2 [cytosol]

PSMD2 [nucleoplasm]

PSMD2 [secretory granule lumen]

PSMD2 [ficolin-1-rich granule lumen]

Inferred To

PSMD2 [extracellular region] (Bos taurus)

PSMD2 [extracellular region] (Canis familiaris)

PSMD2 [extracellular region] (Gallus gallus)

PSMD2 [extracellular region] (Plasmodium falciparum)

PSMD2 [extracellular region] (Sus scrofa)

rpn1 [extracellular region] (Schizosaccharomyces pombe)

Rpn1 [extracellular region] (Drosophila melanogaster)

Psmd2 [extracellular region] (Mus musculus)

Psmd2 [extracellular region] (Rattus norvegicus)

psmd2 [extracellular region] (Xenopus tropicalis)

RPN1 [extracellular region] (Saccharomyces cerevisiae)

rpn-1 [extracellular region] (Caenorhabditis elegans)

psmD2 [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001265637.1, NP_002799.3, NP_001265638.1

OpenTargets

ENSG00000175166

ENSEMBL

ENST00000310118, ENSP00000402618, ENST00000435761, ENST00000439383, ENSP00000416028, ENSP00000310129

HPA

ENSG00000175166-PSMD2

PRO

Q13200

Pharos - Targets

Q13200

GlyGen

Q13200

PDB

5VFQ, 5VFP, 6MSK, 7UIH, 7W3H, 7W3J, 5VFS, 7W3M, 7W3K, 5GJQ, 6WJN, 5VHR, 7W37, 5VHJ, 7QXW, 7W38, 7QYA, 5VHP, 7W3I, 6MSH, 5T0H, 8CVT, 5VHN, 6MSG, 5L4K, 7QXN, 7QXP, 5T0I, 7UJD, 5VHH, 6WJD, 5VFU, 5VFR, 5VHF, 6MSJ, 7W3G, 7QXU, 7W3B, 5VFT, 7QY7, 7QXX, 7W3C, 5T0C, 7W3F, 6MSD, 5VHQ, 5VHI, 7W39, 7QYB, 7W3A, 5VHO, 5LN3, 6MSB, 5T0G, 5GJR, 5VHM, 5VHS, 5T0J

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.958	19
UniProt:Q8WVY7 UBCP1			0.871	14
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.848	7
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.834	9
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.823	14
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.8	8
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.784	7
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.775	6
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.725	6
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.712	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	17
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.695	5
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.669	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.669	4
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	5
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.669	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	5
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.669	5
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.648	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	5
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.643	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.643	5
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.61	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:Q13148 TADBP			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	3
UniProt:Q9Y2B5 VP9D1			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:Q53XL8 Q53XL8			0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	3
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.527	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:Q9UHE8 STEA1			0.488	2

Cite Us!