Reactome | PSMC3 [extracellular region]

PSMC3 [extracellular region]

Stable Identifier

R-HSA-6806496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

26S protease regulatory subunit 6A, TAT-binding protein 1, TBP-1, Proteasome subunit P50

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17980 PSMC3

Gene Names

PSMC3, TBP1

Chain

chain:1-439

Reference Genes

BioGPS Gene:5702 PSMC3

COSMIC (genes):PSMC3 PSMC3

CTD Gene:5702 PSMC3

dbSNP Gene:5702 PSMC3

ENSEMBL:ENSG00000165916.9 PSMC3

HGNC:9549 PSMC3

KEGG Gene (Homo sapiens):5702 PSMC3

Monarch:5702 PSMC3

NCBI Gene:5702 PSMC3

OMIM:186852 PSMC3

UCSC:P17980 PSMC3

Reference Transcript

RefSeq:NM_002804.4 PSMC3

Other Identifiers

11715815_a_at

16738023

201267_PM_s_at

201267_s_at

3164161

3164167

3164172

3164173

3372212

3372213

3372215

3372216

3372217

3372218

3372219

3372220

3372221

3372222

3372223

3372224

3372225

3372226

3372227

3372229

3372230

5702

592_at

7947867

A_23_P104607

GE61288

GO:0000166

GO:0000502

GO:0000932

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0036402

GO:0042802

GO:0043161

GO:0043226

GO:0043921

GO:0045944

GO:0140657

GO:1901800

GO:1904813

HMNXSV003034992

Hs.250758.0.S1_3p_s_at

ILMN_1809010

M34079_at

PH_hs_0028031

TC11001738.hg

Participates

as a member of

Other forms of this molecule

PSMC3 [secretory granule lumen]

PSMC3 [ficolin-1-rich granule lumen]

PSMC3 [nucleoplasm]

PSMC3 [cytosol]

Inferred To

Rpt5 [extracellular region] (Drosophila melanogaster)

psmc3 [extracellular region] (Xenopus tropicalis)

PSMC3 [extracellular region] (Bos taurus)

PSMC3 [extracellular region] (Caenorhabditis elegans)

PSMC3 [extracellular region] (Canis familiaris)

PSMC3 [extracellular region] (Danio rerio)

PSMC3 [extracellular region] (Dictyostelium discoideum)

PSMC3 [extracellular region] (Gallus gallus)

PSMC3 [extracellular region] (Mus musculus)

PSMC3 [extracellular region] (Plasmodium falciparum)

PSMC3 [extracellular region] (Rattus norvegicus)

PSMC3 [extracellular region] (Saccharomyces cerevisiae)

PSMC3 [extracellular region] (Schizosaccharomyces pombe)

PSMC3 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002795.2

OpenTargets

ENSG00000165916

GeneCards

P17980

HPA

ENSG00000165916-PSMC3

Ensembl

ENST00000619920, ENSG00000165916, ENSP00000298852, ENSP00000481029, ENST00000298852

PRO

P17980

Pharos - Targets

P17980

PDB

6MSE, 7W3J, 7W3K, 5VFT, 6MSG, 5VHO, 5VFS, 6MSH, 5VGZ, 7W3M, 5LN3, 6WJD, 5VHN, 5VFR, 7W3C, 6MSJ, 5VHM, 7W3F, 5VFQ, 8CVT, 6WJN, 7W37, 5VHH, 6MSD, 5VHF, 5VFU, 7W3A, 5GJR, 5VHP, 5VHQ, 5GJQ, 5T0C, 5VHR, 5M32, 7W3B, 5VHS, 5T0J, 6MSK, 7W3G, 5VFP, 5VHJ, 5L4G, 5T0I, 7W3H, 7W38, 5VHI, 6MSB, 7W3I, 5T0H, 7W39, 5T0G

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.919	16
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:O14561 NDUFAB1	3	Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925)	0.556	6
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	6
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.547	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3

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