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DDX3X [extracellular region]
Stable Identifier
R-HSA-6806507
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ATP-dependent RNA helicase DDX3X ecNumber3.6.4.13/ecNumber, DDX3X_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
DDX3X [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
DDX3X [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00571 DDX3X
Gene Names
DDX3X, DBX, DDX3
Chain
initiator methionine:, chain:2-662
Reference Genes
BioGPS Gene:1654 DDX3X
COSMIC (genes):DDX3X DDX3X
CTD Gene:1654 DDX3X
dbSNP Gene:1654 DDX3X
ENSEMBL:ENSG00000215301 DDX3X
ENSEMBL_homo_sapiens_GENE:ENSG00000215301.11 DDX3X
HGNC:2745 DDX3X
KEGG Gene (Homo sapiens):1654 DDX3X
Monarch:1654 DDX3X
NCBI Gene:1654 DDX3X
OMIM:300160 DDX3X
UCSC:O00571 DDX3X
Reference Transcript
RefSeq:NM_001193416.2 DDX3X
RefSeq:NM_001356.4 DDX3X
RefSeq:NM_001193417.2 DDX3X
Other Identifiers
11715903_at
11715904_s_at
11715905_x_at
11748960_a_at
11750750_a_at
11750751_x_at
11752296_x_at
11758021_s_at
1654
17102755
201210_PM_at
201210_at
201211_PM_s_at
201211_s_at
207617_PM_at
207617_at
212514_3p_x_at
212514_PM_x_at
212514_x_at
212515_PM_s_at
212515_s_at
39744_at
3974845
3974846
3974847
3974848
3974851
3974854
3974856
3974857
3974859
3974861
3974863
3974865
3974866
3974867
3974868
3974870
3974872
3974875
3974876
3974877
3974879
3974880
3974881
3974882
3974883
3974884
3974885
3974886
3974887
3974889
3974891
3974892
4030183
8166876
826_at
87502_at
A_14_P111515
A_23_P125656
A_23_P317654
A_24_P126060
GE54028
GE81012
GO:0000166
GO:0000278
GO:0002376
GO:0003676
GO:0003677
GO:0003678
GO:0003723
GO:0003724
GO:0003729
GO:0003824
GO:0003924
GO:0004386
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005840
GO:0005852
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006413
GO:0006417
GO:0006915
GO:0007059
GO:0007276
GO:0008092
GO:0008134
GO:0008143
GO:0008190
GO:0008625
GO:0009615
GO:0010494
GO:0010501
GO:0010628
GO:0012501
GO:0016020
GO:0016055
GO:0016787
GO:0016887
GO:0017111
GO:0017148
GO:0022414
GO:0022627
GO:0023052
GO:0030027
GO:0030154
GO:0030307
GO:0030308
GO:0031252
GO:0031333
GO:0031369
GO:0031410
GO:0031954
GO:0032481
GO:0032508
GO:0032727
GO:0032728
GO:0033592
GO:0034063
GO:0034157
GO:0034161
GO:0034774
GO:0035556
GO:0035591
GO:0035613
GO:0036211
GO:0036493
GO:0042254
GO:0042256
GO:0042995
GO:0043015
GO:0043024
GO:0043065
GO:0043066
GO:0043154
GO:0043186
GO:0043226
GO:0043273
GO:0043280
GO:0043539
GO:0045070
GO:0045087
GO:0045296
GO:0045727
GO:0045944
GO:0045948
GO:0048027
GO:0055088
GO:0060090
GO:0061702
GO:0065003
GO:0070062
GO:0071243
GO:0071470
GO:0071651
GO:0071902
GO:0072559
GO:0090263
GO:0097193
GO:0098542
GO:0098586
GO:0098772
GO:0140097
GO:0140098
GO:0140657
GO:1900087
GO:1900227
GO:1901223
GO:1901224
GO:1901985
GO:1902042
GO:1902523
GO:1903608
GO:1904813
GO:2001243
HMNXSV003025979
HMNXSV003028541
HMNXSV003034886
Hs.147916.2.A1_3p_a_at
Hs.147916.2.A1_3p_s_at
Hs.147916.2.A1_3p_x_at
Hs.147916.2.A2_3p_a_at
ILMN_1728870
ILMN_1794392
PH_hs_0028290
TC0X000199.hg
U50553_at
g13514812_3p_at
g13514816_3p_at
g3523149_3p_a_at
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
DDX3X [secretory granule lumen]
DDX3X [ficolin-1-rich granule lumen]
Inferred To
LOC100624590 [extracellular region]
(Sus scrofa)
ddx3xb [extracellular region]
(Danio rerio)
DDX3X [extracellular region]
(Bos taurus)
DDX3X [extracellular region]
(Caenorhabditis elegans)
DDX3X [extracellular region]
(Canis familiaris)
DDX3X [extracellular region]
(Dictyostelium discoideum)
DDX3X [extracellular region]
(Drosophila melanogaster)
DDX3X [extracellular region]
(Gallus gallus)
DDX3X [extracellular region]
(Mus musculus)
DDX3X [extracellular region]
(Plasmodium falciparum)
DDX3X [extracellular region]
(Saccharomyces cerevisiae)
DDX3X [extracellular region]
(Schizosaccharomyces pombe)
DDX3X [extracellular region]
(Sus scrofa)
Ddx3 [extracellular region]
(Rattus norvegicus)
Homologues of DDX3X [extracellular region]
(Mus musculus)
Homologues of DDX3X [extracellular region]
(Rattus norvegicus)
Homologues of DDX3X [extracellular region]
(Sus scrofa)
ddx3x [extracellular region]
(Xenopus tropicalis)
Ddx3x [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001347.3
,
NP_001180346.1
,
NP_001180345.1
OpenTargets
ENSG00000215301
ZINC - Substances
DDX3X_HUMAN
ZINC target
O00571
PRO
O00571
PDB
4O2C
,
5E7I
,
5E7J
,
7LIU
,
2JGN
,
6O5F
,
3JRV
,
4O2F
,
5E7M
,
4PX9
,
4O2E
,
2I4I
,
4PXA
,
6CZ5
GeneCards
O00571
HPA
ENSG00000215301-DDX3X
Ensembl
ENST00000629496
,
ENST00000629785
,
ENSP00000494040
,
ENST00000478993
,
ENSP00000486516
,
ENSP00000486720
,
ENST00000644876
,
ENSP00000487224
,
ENST00000630255
,
ENSP00000478443
,
ENSG00000215301
,
ENSP00000392494
,
ENST00000457138
Pharos - Targets
O00571
ZINC - Predictions - Purchasable
DDX3X_HUMAN
Orphanet
22249
HMDB Protein
HMDBP11672
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.789
10
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.775
7
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.697
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
14
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.613
6
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.61
4
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.599
5
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
7
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.557
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.543
4
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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