Reactome | FGR [extracellular region]

FGR [extracellular region]

Stable Identifier

R-HSA-6806524

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

c-FGR, Proto-oncogene tyrosine-protein kinase FGR, FGR_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09769 FGR

Gene Names

FGR, SRC2

Chain

initiator methionine:, chain:2-529

Reference Genes

BioGPS Gene:2268 FGR

COSMIC (genes):FGR FGR

CTD Gene:2268 FGR

dbSNP Gene:2268 FGR

ENSEMBL:ENSG00000000938 FGR

ENSEMBL_homo_sapiens_GENE:ENSG00000000938.13 FGR

HGNC:3697 FGR

KEGG Gene (Homo sapiens):2268 FGR

Monarch:2268 FGR

NCBI Gene:2268 FGR

OMIM:164940 FGR

UCSC:P09769 FGR

Reference Transcript

Other Identifiers

11722480_a_at

16684056

1780_at

208438_PM_s_at

208438_s_at

2268

2403216

2403217

2403218

2403219

2403220

2403223

2403225

2403226

2403228

2403229

2403232

2403233

2403234

2403236

2403237

2403238

2403239

2403240

2403241

2403242

2403243

2403249

7914112

A_23_P103932

A_24_P316634

A_24_P51517

GE79451

GO:0000166

GO:0001784

GO:0001819

GO:0002376

GO:0002768

GO:0002862

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005743

GO:0005758

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0006954

GO:0007169

GO:0007229

GO:0008360

GO:0009615

GO:0015629

GO:0016020

GO:0016192

GO:0016235

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019901

GO:0023052

GO:0030154

GO:0030282

GO:0030335

GO:0031234

GO:0031410

GO:0032587

GO:0032815

GO:0034774

GO:0034987

GO:0034988

GO:0036211

GO:0038096

GO:0042995

GO:0043226

GO:0043306

GO:0045087

GO:0045088

GO:0045859

GO:0046777

GO:0048705

GO:0048856

GO:0048870

GO:0050764

GO:0050830

GO:0051450

GO:0051897

GO:0070062

GO:0098542

GO:0140096

HMNXSV003020132

ILMN_1795158

ILMN_2272519

ILMN_2368318

M19722_at

PH_hs_0000190

TC01002410.hg

g4885234_3p_a_at

Participates

as a member of

Secretory granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

FGR [secretory granule lumen]

FGR [cytosol]

Inferred To

FGR [extracellular region] (Bos taurus)

FGR [extracellular region] (Caenorhabditis elegans)

FGR [extracellular region] (Canis familiaris)

FGR [extracellular region] (Danio rerio)

FGR [extracellular region] (Drosophila melanogaster)

FGR [extracellular region] (Gallus gallus)

FGR [extracellular region] (Mus musculus)

FGR [extracellular region] (Rattus norvegicus)

FGR [extracellular region] (Sus scrofa)

FGR [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001036212.1, XP_006710515.1, XP_011539312.1, NP_005239.1, NP_001036194.1

ZINC - World Drugs

FGR_HUMAN

Guide to Pharmacology - Targets

2024

OpenTargets

ENSG00000000938

ZINC - FDA approved

FGR_HUMAN

ZINC - Substances

FGR_HUMAN

ZINC - Biogenic

FGR_HUMAN

ZINC target

P09769

PRO

P09769

PDB

7UY3, 7JT9, 7UY0

ZINC - Investigational

FGR_HUMAN

HPA

ENSG00000000938-FGR

GeneCards

P09769

Ensembl

ENST00000374004, ENSP00000363116, ENSG00000000938, ENSP00000363117, ENSP00000382126, ENST00000399173, ENST00000374003, ENST00000374005, ENSP00000363115

Pharos - Targets

P09769

ZINC - Predictions - Purchasable

FGR_HUMAN

HMDB Protein

HMDBP01391

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.643	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.641	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.527	3

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