Reactome | NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs

NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs

Stable Identifier

R-HSA-6806877

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs

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Nucleoside diphosphate kinases (NMEs) play an important role in the reversible phosphorylation of nuceloside diphosphates (NDP) other than ADP to form nuceloside triphosphates (NTP). The gamma phosphate of ATP is transferred to the beta phosphate on NDP via a ping-pong mechanism, using a phosphorylated active-site intermediate. Nucleoside diphosphate kinase 3 (NME3, aka nm23-H3) can readily form mixed hexamers with NME1, consistent with well-characterised NME family members. The overexpression of the NME3 gene inhibits differentiation and induces the apoptosis of myeloid precursor cell lines (Erent et al. 2001). A putative nucleoside diphosphate kinase (NME2P1) is proposed to perform the same NDPK function as NME1:NME3 heterohexamer based on sequence similarity.

Literature References

PubMed ID	Title	Journal	Year
11277919	Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene Konrad, M, Agou, F, Lacombe, ML, Sarger, C, Raschella, G, Lascu, I, Giartosio, A, Cherfils, J, Tissier, P, Erent, M, Gonin, P	Eur J Biochem	2001