APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX

Stable Identifier
Reaction [transition]
Homo sapiens
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NAD(P)H-hydrate epimerase (APOA1BP) is a homodimeric protein located in the mitochondrion (Ritter et al. 2002). Mammalian APOA1BP is able to mediate the epimerisation of the R-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (Marbaix et al. 2011). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Literature References
PubMed ID Title Journal Year
11991719 Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I

Schmitz, G, Schmitz-Madry, A, Boettcher, A, Orsó, E, Fricker, G, Ritter, M, Schmiedeknecht, G, Bared, SM, Barlage, S, Baehr, CH, Buechler, C

Genomics 2002
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Linster, CL, Vertommen, D, Noel, G, Detroux, AM, Van Schaftingen, E, Marbaix, AY

J. Biol. Chem. 2011
Catalyst Activity

NADPHX epimerase activity of APOA1BP dimer [mitochondrial matrix]

Orthologous Events
Cross References
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