CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier
R-HSA-6806967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).
Literature References
PubMed ID Title Journal Year
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Linster, CL, Vertommen, D, Noel, G, Detroux, AM, Van Schaftingen, E, Marbaix, AY

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!