Reactome | PTEN undergoes monoubiquitination

PTEN undergoes monoubiquitination

Stable Identifier

R-HSA-6807106

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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When present at low levels in the cell, the E3 ubiquitin ligase XIAP monoubiquitinates PTEN (Van Themsche et al. 2009). NEDD4 (NEDD4-1) can also monoubiquitinate PTEN (Trotman et al. 2007). Monoubiquitination of PTEN on at least lysine residues K13 and K289 causes translocation of PTEN from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19473982	X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization Van Themsche, C, Parent, S, Leblanc, V, Asselin, E	J. Biol. Chem.	2009
17218261	Ubiquitination regulates PTEN nuclear import and tumor suppression Trotman, LC, Wang, X, Carver, BS, Jiang, X, Pavletich, NP, Tempst, P, Erdjument-Bromage, H, Teruya-Feldstein, J, Pandolfi, PP, Misteli, T, Cordon-Cardo, C, Chen, Z, Kim, HJ, Chi, SG, Yang, H, Alimonti, A	Cell	2007