Reactome | USP13 and OTUD3 deubiquitinate PTEN

USP13 and OTUD3 deubiquitinate PTEN

Stable Identifier

R-HSA-6807206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Several ubiquitin proteases deubiquitinate polyubiquitinated PTEN. USP13 and OTUD3 prolong the half-life of PTEN by preventing its proteasome-mediated degradation. Loss of USP13 or OTUD3 expression promotes AKT activation and cancer aggressiveness (Zhang et al. 2013, Yuan et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26280536	Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis Lv, Y, Zhang, Y, Xiao, ZX, Song, S, Xing, G, Gao, H, Li, H, Zhou, T, Wei, W, Kong, X, Yin, Y, Wang, L, He, F, Gao, D, Li, Y, Yuan, L, Zhang, L	Nat. Cell Biol.	2015
24270891	Deubiquitylation and stabilization of PTEN by USP13 Ma, L, Wang, W, Chen, D, Chen, J, Sun, Y, Wang, M, Maddika, S, Piao, HL, Hung, MC, Wei, Y, Zhang, P, Zhang, J	Nat. Cell Biol.	2013