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WWP2 [cytosol]
Stable Identifier
R-HSA-6807279
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDD4-like E3 ubiquitin-protein ligase WWP2, AIP2, Atrophin-1-interacting protein 2, WW domain-containing protein 2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NOTCH3 binds WWP2 (Homo sapiens)
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
WWP2 ubiquitinates NOTCH3 (Homo sapiens)
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
Ub-NEXT3,Ub-NICD3:WWP2 [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ binds effectors at the plasma membrane (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
RHOU binds effectors at the plasma membrane (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
WWP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00308 WWP2
Gene Names
WWP2
Chain
chain:1-870
Reference Genes
BioGPS Gene:11060 WWP2
COSMIC (genes):WWP2 WWP2
CTD Gene:11060 WWP2
dbSNP Gene:11060 WWP2
ENSEMBL:ENSG00000198373 WWP2
HGNC:16804 WWP2
KEGG:hsa:11060 WWP2
Monarch:11060 WWP2
NCBI Gene:11060 WWP2
OMIM:602308 WWP2
UCSC:O00308 WWP2
Reference Transcript
RefSeq:NM_001270454.1 WWP2
RefSeq:NM_007014.4 WWP2
RefSeq:NM_001270455.1 WWP2
RefSeq:XM_011522825.1 WWP2
RefSeq:NM_199424.2 WWP2
RefSeq:XM_011522826.2 WWP2
RefSeq:XM_017022880.1 WWP2
RefSeq:XM_017022879.1 WWP2
RefSeq:XM_017022881.1 WWP2
RefSeq:NM_001270453.1 WWP2
RefSeq:XM_011522823.2 WWP2
Other Identifiers
11060
11718924_a_at
11718925_a_at
11736645_at
11736646_at
11747600_a_at
11748070_a_at
11752566_a_at
11762625_x_at
1552737_PM_s_at
1552737_s_at
16820620
204022_PM_at
204022_at
210200_PM_at
210200_at
33629_at
3666898
3666903
3666905
3666906
3666907
3666909
3666910
3666911
3666912
3666913
3666914
3666917
3666918
3666919
3666926
3666927
3666928
3666932
3666933
3666934
3666938
3666939
3666940
3666942
3666950
3666951
3666954
3666955
3666957
3666958
3666959
3666961
3666962
3666963
3666964
3666965
3666967
3666968
3666969
3666970
3666971
3666972
3666973
3666974
3666975
3666976
3666977
3666982
3666983
47640_at
48400_r_at
785_at
7996976
90864_i_at
90866_r_at
A_14_P108549
A_14_P117208
A_14_P130126
A_23_P206684
A_23_P357147
A_24_P342086
GE56911
GE81710
GO:0000122
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006511
GO:0006858
GO:0006915
GO:0008134
GO:0010629
GO:0012501
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0032410
GO:0034765
GO:0035329
GO:0036211
GO:0042127
GO:0042391
GO:0043161
GO:0043226
GO:0043433
GO:0045746
GO:0045892
GO:0045944
GO:0046718
GO:0051224
GO:0051865
GO:0060090
GO:0061629
GO:0061630
GO:0070062
GO:0070534
GO:0140096
GO:1901016
HMNXSV003042034
HMNXSV003049655
Hs.315493.0.S2_3p_at
Hs.315493.0.S2_3p_x_at
Hs2.333382.1.S1_3p_s_at
ILMN_1659703
ILMN_1668847
ILMN_1759173
PH_hs_0023763
TC16000571.hg
U96114_at
g12652716_3p_at
Participates
as a candidate of
RHOQ effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a component of
Ub-NEXT3,Ub-NICD3:WWP2 [cytosol] (Homo sapiens)
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
as an input of
NOTCH3 binds WWP2 (Homo sapiens)
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)
Inferred To
pub1 [cytosol]
(Schizosaccharomyces pombe)
RSP5 [cytosol]
(Saccharomyces cerevisiae)
Homologues of WWP2 [cytosol]
(Dictyostelium discoideum)
Homologues of WWP2 [cytosol]
(Schizosaccharomyces pombe)
Su(dx) [cytosol]
(Drosophila melanogaster)
pub3 [cytosol]
(Schizosaccharomyces pombe)
WWP2 [cytosol]
(Bos taurus)
WWP2 [cytosol]
(Canis familiaris)
WWP2 [cytosol]
(Dictyostelium discoideum)
WWP2 [cytosol]
(Gallus gallus)
WWP2 [cytosol]
(Sus scrofa)
wwp-1 [cytosol]
(Caenorhabditis elegans)
wwp2 [cytosol]
(Xenopus tropicalis)
Wwp2 [cytosol]
(Mus musculus)
Wwp2 [cytosol]
(Rattus norvegicus)
pub2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_008945.2
,
XP_011521127.1
,
XP_011521125.1
,
NP_955456.1
,
NP_001257384.1
,
NP_001257383.1
,
NP_001257382.1
,
XP_016878368.1
,
XP_016878370.1
,
XP_016878369.1
,
XP_011521128.1
OpenTargets
ENSG00000198373
ENSEMBL
ENSP00000352069
,
ENST00000359154
,
ENST00000569174
,
ENST00000356003
,
ENSP00000456216
,
ENSP00000348283
,
ENSP00000455311
,
ENST00000568684
HPA
ENSG00000198373-WWP2
PRO
O00308
Pharos - Targets
O00308
GlyGen
O00308
HMDB Protein
HMDBP09263
PDB
5TJQ
,
4Y07
,
5TJ8
,
5TJ7
,
6J1Z
,
6RSS
,
8EI8
,
8EI5
,
8EI6
,
9EQH
,
8EI7
Interactors (74)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BUJ2 HNRNPUL1
1
HNRNPUL1 [nucleoplasm]
(R-HSA-72106)
0.87
9
UniProt:Q8N5I2 ARRD1
0.847
8
UniProt:Q15884 EREP1
0.807
6
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.8
6
UniProt:Q9BUZ4 TRAF4
0.781
7
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.779
7
UniProt:Q3B8N2 LEG9B
0.742
5
UniProt:A5D8V6 VPS37C
1
VPS37C [endosome membrane]
(R-HSA-184438)
0.718
6
UniProt:Q96B67 ARRD3
0.697
5
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.666
5
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.666
4
UniProt:Q8N8A2 ANR44
0.666
5
UniProt:Q9Y3C5 RNF11
0.666
7
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
0.659
4
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
SMAD2 [cytosol]
(R-HSA-3006353)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-9773843)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
p-S250-SMAD2 [cytosol]
(R-HSA-9731121)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
0.656
4
UniProt:Q01860 POU5F1 (OCT4)
1
POU5F1 [nucleoplasm]
(R-HSA-452472)
0.645
4
UniProt:O15105 SMAD7
2
SMAD7 [nucleoplasm]
(R-HSA-178197)
SMAD7 [cytosol]
(R-HSA-173478)
0.591
5
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
6
UniProt:Q08909 YO385
0.556
3
UniProt:Q99954 SMR3A
0.556
3
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.556
3
UniProt:P09234 SNRPC
1
SNRPC [nucleoplasm]
(R-HSA-8865876)
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:Q9NWW5 CLN6
0.556
3
UniProt:O43933 PEX1
1
PEX1 [cytosol]
(R-HSA-9033116)
0.556
3
UniProt:Q86UU5 GGN
0.556
3
UniProt:Q15599 NHRF2
0.556
3
UniProt:P07686 HEXB
11
HEXB S62L [lysosomal lumen]
(R-HSA-3700901)
HEXB R284* [lysosomal lumen]
(R-HSA-3700930)
HEXB M26Cfs*5 [lysosomal lumen]
(R-HSA-3700843)
HEXB I322Kfs*5 [lysosomal lumen]
(R-HSA-3700889)
HEXB(316-556) [lysosomal lumen]
(R-HSA-1605605)
HEXB(122-311) [azurophil granule lumen]
(R-HSA-6799125)
HEXB(315-556) [azurophil granule lumen]
(R-HSA-6799134)
HEXB(122-311) [extracellular region]
(R-HSA-6806190)
HEXB(315-556) [extracellular region]
(R-HSA-6806188)
HEXB(50-107) [lysosomal lumen]
(R-HSA-9842398)
HEXB(122-311) [lysosomal lumen]
(R-HSA-1605777)
0.556
3
UniProt:Q969T4 UBE2E3
4
UBE2E3 [cytosol]
(R-HSA-947633)
UBE2E3 [nucleoplasm]
(R-HSA-8852108)
Ub-C145-UBE2E3 [nucleoplasm]
(R-HSA-8864208)
Ub-C145-UBE2E3 [cytosol]
(R-HSA-8864162)
0.556
3
UniProt:P40325 HUA1
0.556
3
UniProt:Q8WU02 Q8WU02
0.556
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q96D16 Q96D16
0.556
3
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.556
6
UniProt:Q9HBE1-4 PATZ1
0.556
3
UniProt:Q8IZ03 Q8IZ03
0.556
3
UniProt:P07339 CTSD
12
CTSD(65-412) [extracellular region]
(R-HSA-2990853)
CTSD(65-412) [plasma membrane]
(R-HSA-2990852)
CTSD(169-412) [endosome lumen]
(R-HSA-9816128)
CTSD(65-161) [endosome lumen]
(R-HSA-9816123)
CTSD(65-412) [specific granule lumen]
(R-HSA-6801272)
CTSD(65-412) [tertiary granule lumen]
(R-HSA-6801276)
CTSD(65-412) [ficolin-1-rich granule lumen]
(R-HSA-6801321)
CTSD(169-412) [extracellular region]
(R-HSA-2471614)
CTSD(65-161) [extracellular region]
(R-HSA-2228718)
CTSD(65-412) [lysosomal lumen]
(R-HSA-1181223)
CTSD(169-412) [lysosomal lumen]
(R-HSA-9023737)
CTSD(65-161) [lysosomal lumen]
(R-HSA-9023739)
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P22314 UBA1
2
UBA1 [cytosol]
(R-HSA-947698)
UBA1 [nucleoplasm]
(R-HSA-8852116)
0.556
3
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:O14773 TPP1
1
TPP1 [lysosomal lumen]
(R-HSA-535504)
0.556
3
UniProt:Q7L5A3 ATOSB
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q8NHY3 GA2L2
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:Q14204 DYNC1H1
3
DYNC1H1 [cytosol]
(R-HSA-380285)
DYNC1H1 [azurophil granule lumen]
(R-HSA-6799155)
DYNC1H1 [extracellular region]
(R-HSA-6806223)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:Q9BVN2 RUSC1
0.556
3
UniProt:Q9HAC8 UBTD1
0.556
3
UniProt:Q96LR5 UBE2E2
1
UBE2E2 [cytosol]
(R-HSA-947626)
0.556
3
UniProt:P14678-2 SNRPB
0.556
3
UniProt:Q8N7B9-2 EFCAB3
0.556
3
UniProt:Q99732 LITAF
0.556
3
UniProt:Q9Y272 RASD1
0.556
3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4
0.556
3
UniProt:Q13148 TADBP
0.556
3
UniProt:Q5TAL4 Q5TAL4
0.556
3
UniProt:Q96ME1 FBXL18
1
FBXL18 [cytosol]
(R-HSA-8854063)
0.553
2
UniProt:Q8NCT1 ARRD4
0.527
2
UniProt:P24928 POLR2A
7
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
0.527
3
UniProt:Q9NW97 TMM51
0.527
2
UniProt:Q5JRV8 T255A
0.527
2
UniProt:Q9H3M7 TXNIP
2
TXNIP [cytosol]
(R-HSA-1250246)
TXNIP [nucleoplasm]
(R-HSA-9617747)
0.527
2
UniProt:P03120 VE2
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
2
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.488
2
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