Reactome | CPSF3L [nucleoplasm]

CPSF3L [nucleoplasm]

Stable Identifier

R-HSA-6807411

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 11, INT11_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        CPSF3L [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5TA45 CPSF3L

Gene Names

CPSF3L, INTS11, RC68

Chain

chain:1-600

Reference Genes

BioGPS Gene:54973 CPSF3L

COSMIC (genes):INTS11 CPSF3L

CTD Gene:54973 CPSF3L

dbSNP Gene:54973 CPSF3L

ENSEMBL:ENSG00000127054 CPSF3L

HGNC:26052 CPSF3L

KEGG:hsa:54973 CPSF3L

Monarch:54973 CPSF3L

NCBI Gene:54973 CPSF3L

OMIM:611354 CPSF3L

UCSC:Q5TA45 CPSF3L

Reference Transcript

Other Identifiers

11728194_x_at

11754890_x_at

16680184

217994_PM_x_at

217994_x_at

224312_PM_x_at

224312_x_at

232437_PM_at

232437_at

233563_PM_s_at

233563_s_at

233625_PM_x_at

233625_x_at

2391359

2391361

2391362

2391363

2391364

2391365

2391366

2391367

2391368

2391369

2391370

2391371

2391372

2391373

2391374

2391375

2391376

2391377

2391378

2391379

2391380

2391381

2391382

2391383

2391384

2391385

2391386

2391387

2391388

2391389

2391390

2391391

2391392

2391393

2391394

2391396

2391397

2391398

2391399

2391400

2391401

2391402

2391403

2391404

2391405

2391406

2391407

2391408

2391409

2391410

2391411

2391412

2391413

2391414

2391417

2391418

2391419

2391421

2391422

4041784

43402_at

45401_s_at

50164_at

54973

78680_at

7911486

A_23_P35030

A_24_P328231

A_33_P3270802

GE55544

GE84088

GE85068

GE88603

GO:0003824

GO:0004521

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0016073

GO:0016180

GO:0016787

GO:0032039

GO:0034243

GO:0043226

GO:0072562

GO:0140098

HMNXSV003026062

HMNXSV003029318

HMNXSV003043871

Hs.134740.0.S1_3p_at

Hs.6449.3.S1_3p_x_at

Hs.6449.4.A1_3p_a_at

ILMN_1718013

ILMN_1762316

PH_hs_0000648

TC01002091.hg

g12653778_3p_x_at

g8923511_3p_x_at

p26

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

cpsf3l [nucleoplasm] (Danio rerio)

Ints11 [nucleoplasm] (Mus musculus)

Ints11 [nucleoplasm] (Rattus norvegicus)

INTS11 [nucleoplasm] (Bos taurus)

INTS11 [nucleoplasm] (Canis familiaris)

INTS11 [nucleoplasm] (Sus scrofa)

ints11 [nucleoplasm] (Dictyostelium discoideum)

ints11 [nucleoplasm] (Xenopus tropicalis)

ints-11 [nucleoplasm] (Caenorhabditis elegans)

CPSF3L [nucleoplasm] (Gallus gallus)

IntS11 [nucleoplasm] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000127054

ENSEMBL

ENSP00000404886, ENST00000545578, ENSP00000413493, ENST00000419704, ENST00000435064, ENST00000540437, ENSP00000392848, ENSP00000444672, ENST00000450926, ENSP00000445001

HPA

ENSG00000127054-INTS11

PRO

Q5TA45

Pharos - Targets

Q5TA45

PDB

7PKS, 8RC4, 5V8W, 7YCX, 7CUN, 7BFP, 7BFQ, 8RBX, 8RBZ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95947 TBX6	1	TBX6 [nucleoplasm] (R-HSA-9793377)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.527	2