Reactome | ICE2 [nucleoplasm]

ICE2 [nucleoplasm]

Stable Identifier

R-HSA-6807421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Little elongation complex subunit 2, ICE2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ICE2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q659A1 ICE2

Gene Names

ICE2, BRCC1, NARG2, UNQ3101/PRO10100

Chain

chain:1-982

Reference Genes

BioGPS Gene:79664 ICE2

COSMIC (genes):ICE2 ICE2

CTD Gene:79664 ICE2

dbSNP Gene:79664 ICE2

ENSEMBL:ENSG00000128915 ICE2

HGNC:29885 ICE2

KEGG:hsa:79664 ICE2

Monarch:79664 ICE2

NCBI Gene:79664 ICE2

OMIM:610835 ICE2

UCSC:Q659A1 ICE2

Reference Transcript

Other Identifiers

11722630_a_at

11722631_s_at

11722632_x_at

11722633_a_at

11722634_a_at

11747983_a_at

11747984_x_at

16810104

218713_PM_at

218713_at

228960_PM_at

228960_at

235189_PM_at

235189_at

242639_PM_at

242639_at

2632213

2797878

3627362

3627364

3627365

3627366

3627367

3627368

3627373

3627374

3627376

3627378

3627380

3627381

3627382

3627383

3627384

3627387

3627388

3627389

3627390

3627391

3627392

3627393

3627394

3627395

3627396

3627397

3627398

3627399

3627402

3627403

3627404

3627405

3627406

3627409

3627411

3627412

3627413

3627414

3627415

61313_at

65633_at

68959_at

79664

7989347

79987_at

80017_at

A_24_P914972

A_32_P115701

A_32_P129419

GE79820

GE87769

GO:0000791

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0008023

GO:0015030

GO:0016073

GO:0016604

GO:0035363

GO:0042795

GO:0042796

GO:0043226

GO:0045945

HMNXSV003051614

Hs.145704.0.A1_3p_at

Hs.200943.0.A1_3p_at

Hs.29263.1.A1_3p_at

ILMN_1666610

ILMN_1718830

ILMN_2346460

PH_hs_0035684

TC15001506.hg

TC15002562.hg

g13375822_3p_at

Participates

as a component of

LEC [nucleoplasm] (Homo sapiens)

Inferred To

ICE2 [nucleoplasm] (Bos taurus)

ICE2 [nucleoplasm] (Canis familiaris)

ICE2 [nucleoplasm] (Dictyostelium discoideum)

ICE2 [nucleoplasm] (Gallus gallus)

ICE2 [nucleoplasm] (Sus scrofa)

Ghost homologue of ICE2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ICE2 [nucleoplasm] (Danio rerio)

Ghost homologue of ICE2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of ICE2 [nucleoplasm] (Xenopus tropicalis)

Ice2 [nucleoplasm] (Mus musculus)

Ice2 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000558181, ENSP00000453593, ENST00000560668, ENSP00000261520, ENST00000261520, ENSG00000128915, ENSP00000453303

OpenTargets

ENSG00000128915

GeneCards

ICE2

HPA

ENSG00000128915-ICE2

PRO

Q659A1

Pharos - Targets

Q659A1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.643	6
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.623	5
UniProt:P02788 LTF	4	LTF [phagocytic vesicle lumen] (R-HSA-1222567) LTF [extracellular region] (R-HSA-977171) LTF [tertiary granule lumen] (R-HSA-6800962) LTF [specific granule lumen] (R-HSA-6799629)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:P08311 CTSG	4	CTSG [cytosol] (R-HSA-9635429) CTSG [extracellular region] (R-HSA-2228716) CTSG [plasma membrane] (R-HSA-538738) CTSG [azurophil granule lumen] (R-HSA-6799137)	0.527	2