Reactome | ASUN [nucleoplasm]

ASUN [nucleoplasm]

Stable Identifier

R-HSA-6807447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein asunder homolog, ASUN_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVM9 ASUN

Gene Names

ASUN, C12orf11, GCT1, INTS13

Chain

chain:1-706

Reference Genes

BioGPS Gene:55726 ASUN

CTD Gene:55726 ASUN

dbSNP Gene:55726 ASUN

ENSEMBL:ENSG00000064102 ASUN

ENSEMBL_homo_sapiens_GENE:ENSG00000064102.15 ASUN

HGNC:20174 ASUN

KEGG Gene (Homo sapiens):55726 ASUN

Monarch:55726 ASUN

NCBI Gene:55726 ASUN

OMIM:615079 ASUN

UCSC:Q9NVM9 ASUN

Reference Transcript

Other Identifiers

11744221_a_at

11744907_a_at

16762573

221652_PM_s_at

221652_s_at

3448429

3448430

3448431

3448432

3448435

3448439

3448440

3448441

3448442

3448443

3448444

3448445

3448446

3448447

3448448

3448449

3448450

3448452

3448453

3448454

3448456

3448457

3448459

3448460

3448461

55726

56315_at

72373_at

7961964

A_23_P36464

A_33_P3232280

GE82312

GO:0000278

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006351

GO:0006355

GO:0007010

GO:0007018

GO:0007049

GO:0007052

GO:0007346

GO:0016073

GO:0016180

GO:0016604

GO:0022414

GO:0030317

GO:0032039

GO:0034243

GO:0043226

GO:0043231

GO:0048870

GO:0051301

GO:0051642

GO:0080154

GO:0090435

HMNXSV003047217

HMNXSV003049385

ILMN_2196337

PH_hs_0001978

TC12001330.hg

g12751064_3p_a_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

INTS13 [nucleoplasm] (Bos taurus)

INTS13 [nucleoplasm] (Canis familiaris)

INTS13 [nucleoplasm] (Gallus gallus)

INTS13 [nucleoplasm] (Sus scrofa)

ASUN [nucleoplasm] (Dictyostelium discoideum)

zgc:55466 [nucleoplasm] (Danio rerio)

Ints13 [nucleoplasm] (Rattus norvegicus)

IntS13 [nucleoplasm] (Mus musculus)

ints-13 [nucleoplasm] (Caenorhabditis elegans)

Homologues of ASUN [nucleoplasm] (Xenopus tropicalis)

Asun [nucleoplasm] (Drosophila melanogaster)

ints13 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_016875121.1, NP_060634.2

GeneCards

Q9NVM9

HPA

ENSG00000064102-INTS13

Ensembl

ENSP00000261191, ENST00000261191, ENSG00000064102

PRO

Q9NVM9

Pharos - Targets

Q9NVM9

PDB

6SN1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.524	2

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