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ELL2 [nucleoplasm]
Stable Identifier
R-HSA-6807506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA polymerase II elongation factor ELL2, ELL2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00472 ELL2
Gene Names
ELL2
Chain
chain:1-640
Reference Genes
BioGPS Gene:22936 ELL2
COSMIC (genes):ELL2 ELL2
CTD Gene:22936 ELL2
dbSNP Gene:22936 ELL2
ENSEMBL:ENSG00000118985 ELL2
HGNC:17064 ELL2
KEGG:hsa:22936 ELL2
Monarch:22936 ELL2
NCBI Gene:22936 ELL2
OMIM:601874 ELL2
UCSC:O00472 ELL2
Reference Transcript
RefSeq:NM_012081.5 ELL2
Other Identifiers
11736477_a_at
11736478_a_at
11749208_a_at
11752840_a_at
11755239_a_at
148_at
16998309
214446_PM_at
214446_at
226099_PM_at
226099_at
226982_PM_at
226982_at
22936
240038_PM_at
240038_at
2439245
2439248
2439257
2439258
2439262
2867874
2867875
2867876
2867877
2867879
2867882
2867887
2867888
2867891
2867892
2867893
2867894
2867895
2867896
2867900
2867901
2867902
2867912
2867913
2867914
2867917
2867934
2867935
2867951
2867952
2867953
2867954
40606_at
46169_at
53313_at
62502_at
68301_at
7921344
8113220
85068_at
A_23_P251011
A_23_P41645
A_23_P58506
GE782298
GE81750
GE86859
GO:0000987
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0006366
GO:0006368
GO:0008023
GO:0016073
GO:0032968
GO:0042795
GO:0043226
HMNXSV003006330
HMNXSV003057953
Hs.173334.0.A1_3p_at
Hs.173334.1.A1_3p_at
Hs.173334.2.S1_3p_at
Hs.192221.0.A1_3p_at
ILMN_1655930
PH_hs_0029396
TC05001610.hg
U88629_at
Participates
as a member of
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
Inferred To
Ell [nucleoplasm]
(Drosophila melanogaster)
ell2 [nucleoplasm]
(Xenopus tropicalis)
Ell2 [nucleoplasm]
(Mus musculus)
Ell2 [nucleoplasm]
(Rattus norvegicus)
ell-1 [nucleoplasm]
(Caenorhabditis elegans)
ELL2 [nucleoplasm]
(Bos taurus)
ELL2 [nucleoplasm]
(Canis familiaris)
ELL2 [nucleoplasm]
(Gallus gallus)
ELL2 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000237853
OpenTargets
ENSG00000118985
HPA
ENSG00000118985-ELL2
PRO
O00472
Pharos - Targets
O00472
PDB
7OKY
,
2E5N
,
5JW9
,
7OKX
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.8
9
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.725
6
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.643
4
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:P07550 ADRB2
5
ADRB2 [plasma membrane]
(R-HSA-390647)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
ADRB2 [endosome membrane]
(R-HSA-6783036)
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
4
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.527
3
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