Reactome | NOX4, NOX5 reduce O2 to O2.-

NOX4, NOX5 reduce O2 to O2.-

Stable Identifier

R-HSA-6807557

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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NADPH oxidases 4 and 5 (NOX4, 5) are ER membrane-bound proteins that generates superoxide (O2.-) in endothelial cells (BelAiba et al. 2007). NOX4 functions in association with cytochrome b heterodimer (CYBA:CYBB) on the ER (and nuclear) membrane (Martyn et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
15927447	Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases von Loehneysen, K, Frederick, LM, Martyn, KD, Dinauer, MC, Knaus, UG	Cell. Signal.	2006
17275676	NOX5 variants are functionally active in endothelial cells Bickel, C, Pogrebniak, A, Görlach, A, Bonello, S, Banfi, B, Djordjevic, T, Petry, A, Diemer, K, Hess, J, BelAiba, RS	Free Radic. Biol. Med.	2007