Reactome | LDHAL6B [mitochondrial matrix]

LDHAL6B [mitochondrial matrix]

Stable Identifier

R-HSA-6807613

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

L-lactate dehydrogenase A-like 6B

Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3

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Literature References

PubMed ID	Title	Journal	Year
19679512	Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs Holmes, RS, Goldberg, E	Comput Biol Chem	2009
15870898	Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis Wang, H, Sha, J, Xu, Z, Zhou, Z, Lu, L	Int. J. Mol. Med.	2005

External Reference Information

External Reference

UniProt:Q9BYZ2 LDHAL6B

Gene Names

LDHAL6B, LDHAL6, LDHL

Chain

chain:1-381

Reference Genes

BioGPS Gene:92483 LDHAL6B

COSMIC (genes):LDHAL6B LDHAL6B

CTD Gene:92483 LDHAL6B

dbSNP Gene:92483 LDHAL6B

ENSEMBL:ENSG00000171989 LDHAL6B

ENSEMBL_homo_sapiens_GENE:ENSG00000171989.6 LDHAL6B

HGNC:21481 LDHAL6B

KEGG Gene (Homo sapiens):92483 LDHAL6B

Monarch:92483 LDHAL6B

NCBI Gene:92483 LDHAL6B

UCSC:Q9BYZ2 LDHAL6B

Reference Transcript

RefSeq:NM_033195.2 LDHAL6B

Other Identifiers

11733930_at

16801573

210712_PM_at

210712_at

3596022

3596023

3596024

3596025

3596026

3596027

7983985

92483

A_14_P136819

A_23_P54357

GE560646

GO:0003824

GO:0004459

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0006089

GO:0006090

GO:0016491

GO:0016616

GO:0019752

GO:0043226

GO:1990204

HMNXSV003036110

ILMN_1719788

ILMN_2151698

PH_hs_0032606

TC15000451.hg

g12330999_3p_at

Inferred To

LDHAL6B [mitochondrial matrix] (Caenorhabditis elegans)

LDHAL6B [mitochondrial matrix] (Canis familiaris)

LDHAL6B [mitochondrial matrix] (Danio rerio)

LDHAL6B [mitochondrial matrix] (Drosophila melanogaster)

LDHAL6B [mitochondrial matrix] (Gallus gallus)

LDHAL6B [mitochondrial matrix] (Mus musculus)

LDHAL6B [mitochondrial matrix] (Rattus norvegicus)

LDHAL6B [mitochondrial matrix] (Xenopus tropicalis)

Homologues of LDHAL6B [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

NP_149972.1

OpenTargets

ENSG00000171989

IntEnz

1.1.1.27

HPA

ENSG00000171989-LDHAL6B

GeneCards

Q9BYZ2

Ensembl

ENSP00000302393, ENSG00000171989, ENST00000307144

PRO

Q9BYZ2

Pharos - Targets

Q9BYZ2

HMDB Protein

HMDBP03581

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13148 TADBP			0.556	6
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.556	3
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.556	3
UniProt:Q9BXM7 PINK1	5	p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.556	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:P49768-2 PSEN1			0.556	6
UniProt:O60260-5 PRKN			0.556	6
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q9NUW8 TDP1	1	TDP1 [nucleoplasm] (R-HSA-175593)	0.556	3
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.556	3
UniProt:P05067-2 APP			0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q5SXM8 DNLZ			0.527	2
UniProt:P46199 MTIF2	1	MTIF2 [mitochondrial matrix] (R-HSA-5368271)	0.527	2
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.524	2
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.488	2
UniProt:Q96JZ2 HSH2D			0.488	2

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