Reactome | ARFGAP3 [cytosol]

ARFGAP3 [cytosol]

Stable Identifier

R-HSA-6807740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP3 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NP61 ARFGAP3

Gene Names

ARFGAP3, ARFGAP1

Chain

chain:1-516

Reference Genes

BioGPS Gene:26286 ARFGAP3

COSMIC (genes):ARFGAP3 ARFGAP3

CTD Gene:26286 ARFGAP3

dbSNP Gene:26286 ARFGAP3

ENSEMBL:ENSG00000242247 ARFGAP3

ENSEMBL_homo_sapiens_GENE:ENSG00000242247.11 ARFGAP3

HGNC:661 ARFGAP3

KEGG Gene (Homo sapiens):26286 ARFGAP3

Monarch:26286 ARFGAP3

NCBI Gene:26286 ARFGAP3

OMIM:612439 ARFGAP3

UCSC:Q9NP61 ARFGAP3

Reference Transcript

Other Identifiers

11717442_s_at

11750980_a_at

16935703

202211_PM_at

202211_at

26286

3962612

3962613

3962614

3962615

3962618

3962619

3962624

3962627

3962628

3962630

3962631

3962635

3962638

3962641

3962646

3962648

3962650

3962651

3962655

3962656

3962661

3962662

39905_i_at

39906_r_at

8076515

A_23_P68970

GE54819

GO:0000139

GO:0005096

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0006886

GO:0009306

GO:0015031

GO:0016020

GO:0016192

GO:0043226

GO:0046872

GO:0048205

GO:0061024

GO:0098772

HMNXSV003044360

ILMN_1731287

ILMN_2227800

PH_hs_0001251

g13477296_3p_at

Participates

as a candidate of

as a member of

ARFGAP1,2,3 [cytosol] (Homo sapiens)

Inferred To

ArfGAP3 [cytosol] (Drosophila melanogaster)

Arfgap3 [cytosol] (Mus musculus)

Arfgap3 [cytosol] (Rattus norvegicus)

GLO3 [cytosol] (Saccharomyces cerevisiae)

glo3 [cytosol] (Schizosaccharomyces pombe)

ARFGAP3 [cytosol] (Bos taurus)

ARFGAP3 [cytosol] (Caenorhabditis elegans)

ARFGAP3 [cytosol] (Canis familiaris)

ARFGAP3 [cytosol] (Dictyostelium discoideum)

ARFGAP3 [cytosol] (Gallus gallus)

ARFGAP3 [cytosol] (Plasmodium falciparum)

ARFGAP3 [cytosol] (Sus scrofa)

arfgap3 [cytosol] (Danio rerio)

arfgap3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001135765.1, NP_055385.3

OpenTargets

ENSG00000242247

GeneCards

Q9NP61

HPA

ENSG00000242247-ARFGAP3

Ensembl

ENST00000263245, ENSP00000388791, ENSP00000263245, ENST00000437119, ENSG00000242247

PRO

Q9NP61

Pharos - Targets

Q9NP61

HMDB Protein

HMDBP08307

PDB

2CRW

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	22
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P17302 GJA1	6	GJA1 [Golgi membrane] (R-HSA-190649) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [lysosomal membrane] (R-HSA-196173) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [plasma membrane] (R-HSA-158058) GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	8

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