Reactome | STX5 [Golgi membrane]

STX5 [Golgi membrane]

Stable Identifier

R-HSA-6807771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Syntaxin 5

Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
        
        STX5 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13190 STX5

Gene Names

STX5, STX5A

Chain

chain:1-355

Reference Genes

COSMIC (genes):STX5 STX5

dbSNP Gene:6811 STX5

ENSEMBL:ENSG00000162236 STX5

Participates

as a member of

other COG interacting snares [Golgi membrane] (Homo sapiens)

as an output of

as a component of

Other forms of this molecule

STX5 [cytosol]

STX5 [ER to Golgi transport vesicle membrane]

STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]

STX5 [endoplasmic reticulum membrane]

Inferred To

SED5 [Golgi membrane] (Saccharomyces cerevisiae)

stx5a [Golgi membrane] (Danio rerio)

Stx5 [Golgi membrane] (Mus musculus)

Stx5 [Golgi membrane] (Rattus norvegicus)

syx-5 [Golgi membrane] (Caenorhabditis elegans)

stx5 [Golgi membrane] (Xenopus tropicalis)

STX5 [Golgi membrane] (Bos taurus)

STX5 [Golgi membrane] (Canis familiaris)

STX5 [Golgi membrane] (Gallus gallus)

STX5 [Golgi membrane] (Plasmodium falciparum)

STX5 [Golgi membrane] (Sus scrofa)

sed5 [Golgi membrane] (Schizosaccharomyces pombe)

Syx5 [Golgi membrane] (Drosophila melanogaster)

syn5 [Golgi membrane] (Dictyostelium discoideum)

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95183 VAMP5			0.742	6
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.738	5
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.718	9
UniProt:Q8N6L0 KASH5			0.718	6
UniProt:P61764 STXBP1	2	STXBP1 [plasma membrane] (R-HSA-2980862) STXBP1 [cytosol] (R-HSA-6794256)	0.718	6
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.718	6
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.669	4
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.666	5
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.666	5
UniProt:Q9UNK0 STX8			0.666	6
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.569	4
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q4LEZ3 AARD			0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:O75410 TACC1			0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q494R4-2 DRC12			0.556	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:Q9BUF7-2 CRB3			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q86VR2 RETR3			0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9HCJ2 LRC4C			0.556	3
UniProt:Q9ULD2-3 MTUS1			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:P38932	1	VPS45 [endosome membrane] (R-SCE-1011607)	0.556	3
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.556	3
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.527	3
UniProt:O15498 YKT6	5	PalmC-YKT6 [Golgi membrane] (R-HSA-6808792) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558)	0.527	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.527	3

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