LDHAL6B reduces PYR to LACT

Stable Identifier
R-HSA-6807826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.
Literature References
PubMed ID Title Journal Year
19679512 Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs

Holmes, RS, Goldberg, E

Comput Biol Chem 2009
15870898 Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis

Wang, H, Sha, J, Xu, Z, Zhou, Z, Lu, L

Int. J. Mol. Med. 2005
Participants
Participates
Catalyst Activity

L-lactate dehydrogenase activity of LDHAL6B [mitochondrial matrix]

Orthologous Events
Cross References
RHEA
Rhea
Authored
Reviewed
Created
Cite Us!