Reactome | ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex

ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex

Stable Identifier

R-HSA-6807875

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)

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ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex

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Binding and polymerization of the coatomer (the COPI coat) is coordinated with the incorporation of cargo proteins and Golgi-targeting snares, as well as with recruitment of ARFGAP proteins (Letourneur et al, 1994; Nagahama et al,1996; Bremser et al, 1999).
Typical model cargo for COPI-mediated trafficking includes the viral glycoprotein VSV-G and proinsulin as well as the KDEL receptors, which bind and recycle ER-resident proteins and which themselves must be returned to post-ER compartments (Cosson and Letourner, 1994; Ben-Tekaya et al, 2005; Majoul et al, 2001; Orci et al, 1997, Bremser et al, 1999; Presley et al, 1997; reviewed in Beck et al, 2009).
Other protein components of the COPI vesicle include the p24 family of proteins, which serve diverse roles in the early secretory pathway (reviewed in Schuiki and Volchuk, 2012). Oligomeric p24 proteins interact with ADP-bound ARF and components of the COPI coat, contributing to coatomer recruitment and oligomerization (Gommel et al, 2001; Majoul et al, 2001; Bethune et al, 2006; Harter and Wieland, 1998; Langer et al, 2008; Reinhard et al, 1999). The p24 proteins also act as cargo receptors for various proteins destined for packaging in COPI vesicles; these include GPI-anchored transmembrane proteins, WNT ligands and some G-protein coupled receptors (Takida et al, 2008; Bonnon et al, 2010; Luo et al, 2011; Beuchling et al, 2011; Wang and Kazanietz, 2002; reviewed in Schuiki and Volchuk, 2012). Finally, the p24 proteins contribute to COPI coat disassembly by restricting ARF GTPase activity until cargo has been loaded (Goldberg, 2000; Lanoix et al, 2001).
ARFGAPs are recruited to the budding vesicle through direct interaction with active ARF, the cytoplasmic tails of cargo proteins and with components of the COPI coat (Goldberg, 2000; Majoul et al, 2001; Aoe et al, 1997; Kliouchnikov et al, 2009; Luo et al, 2009). Stimulation of ARF GTPase activity is coordinated with cargo recruitment to ensure that only cargo-loaded vesicles are produced (Goldberg, 2000; Luo et al, 2009).
Mammalian cells have 3 ARFGAPs that appear to be involved in COPI-mediated traffic, ARFGAP1,2 and 3 (Frigerio et al, 2007; Liu et al, 2001; Kahn et al, 2008). ARFGAP1 has a ALPS domain that recognizes membrane curvature and that is required for the GTPase stimulating activity of the protein, suggesting a mechanism for coordinating ARF1-mediated GTP hydrolysis with vesicle formation (Bigay et al, 2003; Mesmin et al, 2007). ARFGAP 2 and 3 do not contain this motif, and their activity is dependent upon interaction with coatomer (Weimar et al 2008; Kliouchnikov et al, 2009; Luo et al, 2009).
Finally, there is evidence that components of the ankyin/spectrin skeleton may be incorporated in the nascent COPI vesicle, acting as a bridge between cargo proteins and the dynein-dynactin complex required for their transport to the Golgi (Devarajan et al, 1997; Godi et al, 1998; Holleran et al, 1996; Holleran et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
19296914	Arf GAP2 is positively regulated by coatomer and cargo Hayashi, R, Randazzo, PA, Ha, VL, Luo, R	Cell. Signal.	2009
9380700	Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells Morrow, JS, Stabach, PR, Devarajan, P, De Matteis, MA	Proc. Natl. Acad. Sci. U.S.A.	1997
8001155	Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum Riezman, H, Hennecke, S, Emr, SD, Gaynor, EC, Letourneur, F, Cosson, P, Duden, R, Démollière, C	Cell	1994
8128252	Coatomer interaction with di-lysine endoplasmic reticulum retention motifs Letourneur, F, Cosson, P	Science	1994
19015319	Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking Weimer, C, Moelleken, J, Wieland, F, Brugger, B, Eckert, P, Beck, R, Reckmann, I	J. Cell Biol.	2008
11689559	Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain Wang, H, Kazanietz, MG	J. Biol. Chem.	2002
18809720	Consensus nomenclature for the human ArfGAP domain-containing proteins Zapp, ML, Theibert, AB, Inoue, H, Satake, M, Premont, RT, Logsdon, JM, Randazzo, PA, Bruford, E, Nie, Z, Kahn, RA, Cassel, D	J. Cell Biol.	2008
10052452	Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors Söllner, TH, Schweikert, M, Bremser, M, Nickel, W, Hughes, CA, Ravazzola, M, Amherdt, M, Wieland, FT, Rothman, JE	Cell	1999
9288971	ER-to-Golgi transport visualized in living cells Presley, JF, Lippincott-Schwartz, J, Hirschberg, K, Cole, NB, Zaal, KJ, Schroer, TA	Nature	1997
9751720	A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer Harter, C, Wieland, FT	Proc. Natl. Acad. Sci. U.S.A.	1998
11461920	beta III spectrin binds to the Arp1 subunit of dynactin Morrow, JS, Stankewich, MC, Ligon, LA, Tokito, M, Holzbaur, EL, Holleran, EA	J. Biol. Chem.	2001
15632110	Live imaging of bidirectional traffic from the ERGIC Hauri, HP, Ben-Tekaya, H, Pepperkok, R, Miura, K	J. Cell. Sci.	2005
25436559	Diverse roles for the p24 family of proteins in eukaryotic cells Schuiki, I, Volchuk, A	Biomol Concepts	2012
10761932	Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex Goldberg, J	Cell	2000
11172815	Functional characterization of novel human ARFGAP3 Zhang, C, Liu, X, Xing, G, Chen, Q, He, F	FEBS Lett.	2001
17253781	Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature Bigay, J, Drin, G, Rawet, M, Mesmin, B, Levi, S, Antonny, B, Cassel, D	Biochemistry	2007
11703931	KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET Hell, SW, Straub, M, Majoul, I, Söling, HD, Duden, R	Dev. Cell	2001
14654841	Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature Gounon, P, Antonny, B, Bigay, J, Robineau, S	Nature	2003
17760859	Two human ARFGAPs associated with COP-I-coated vesicles Frigerio, G, Majoul, I, Grimsey, N, Dale, M, Duden, R	Traffic	2007
17927562	Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane Kinoshita, T, Maeda, Y, Takida, S	Biochem. J.	2008
16940185	Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins Wieland, F, Brugger, B, Hoffmann, J, Reckmann, I, Kol, M, Béthune, J	Mol. Cell. Biol.	2006
9990005	Receptor-induced polymerization of coatomer Bremser, M, Wieland, F, Sohn, K, Brugger, B, Reinhard, C, Harter, C, Helms, JB	Proc. Natl. Acad. Sci. U.S.A.	1999
22094269	p24 proteins are required for secretion of Wnt ligands Boutros, M, Weiss, M, Buechling, T, Spirohn, K, Chaudhary, V	EMBO Rep.	2011
9405360	The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1 Aoe, T, Cukierman, E, Peters, PJ, Lee, A, Hsu, VW, Cassel, D	EMBO J.	1997
21219331	Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking Wang, Y, Luo, W, Reiser, G	J. Neurochem.	2011
16633337	ARF proteins: roles in membrane traffic and beyond Chavrier, P, D'Souza-Schorey, C	Nat. Rev. Mol. Cell Biol.	2006
18182008	A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET Brugger, B, Wieland, FT, Herten, DP, Stoops, EH, Béthune, J, Roth, CM, Langer, JD	Traffic	2008
20427317	Selective export of human GPI-anchored proteins from the endoplasmic reticulum Hauri, HP, Wendeler, MW, Bonnon, C, Paccaud, JP	J. Cell. Sci.	2010
9671725	ADP ribosylation factor regulates spectrin binding to the Golgi complex Godi, A, Di Tullio, G, Morrow, JS, Santone, I, Stabach, PR, Luini, A, Polishchuk, R, Devarajan, P, Pertile, P, De Matteis, MA, Petrucci, TC	Proc. Natl. Acad. Sci. U.S.A.	1998
11726511	Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 Lottspeich, F, Nickel, W, Reinhard, C, Wieland, FT, Helms, JB, Pfannstiel, J, Heiss, A, Memon, AR, Lechner, J, Gommel, DU	EMBO J.	2001
8991093	Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles Karki, S, Holzbaur, EL, Tokito, MK, Holleran, EA	J. Cell Biol.	1996
19631211	The COPI system: molecular mechanisms and function Rawet, M, Ravet, M, Wieland, FT, Beck, R, Cassel, D	FEBS Lett.	2009
9244307	Bidirectional transport by distinct populations of COPI-coated vesicles Söllner, TH, Perrelet, A, Ravazzola, M, Stamnes, M, Orci, L, Amherdt, M, Rothman, JE	Cell	1997
11748249	Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1 Lanoix, J, Stark, A, Szafer, E, Weiss, M, Dejgaard, K, Nilsson, T, Cassel, D, Ouwendijk, J	J. Cell Biol.	2001
8636227	A v-SNARE implicated in intra-Golgi transport Söllner, TH, Ravazzola, M, Orci, L, Amherdt, M, Rothman, JE, Tempst, P, Nagahama, M, Lacomis, L	J. Cell Biol.	1996
19109418	Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat Goldfeder, N, Bigay, J, Rawet, M, Mesmin, B, Antonny, B, Cassel, D, Parnis, A, Kliouchnikov, L	Mol. Biol. Cell	2009