ARFGAPs stimulate ARF GTPase activity

Stable Identifier
Reaction [transition]
Homo sapiens
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The ARFGAP proteins stimulates ARF GTPase activity, promoting the release of the nascent COPI vesicle from the membrane and release of ARF:ADP (Tanigawa et al, 1993; reviewed in Beck et al, 2009; East and Kahn, 2011). Although this reaction shows their dissociation, it is not clear whether ARFGAPs persist on the COPI vesicle after GTP hydrolysis, nor is it known when GBF is released from the nascent COPI vesicle.

Literature References
PubMed ID Title Journal Year
19631211 The COPI system: molecular mechanisms and function

Rawet, M, Ravet, M, Wieland, FT, Beck, R, Cassel, D

FEBS Lett. 2009
8253837 Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles

Tanigawa, G, Amherdt, M, Rothman, JE, Orci, L, Ravazzola, M, Helms, JB

J. Cell Biol. 1993
20637885 Models for the functions of Arf GAPs

Kahn, RA, East, MP

Semin. Cell Dev. Biol. 2011
Catalyst Activity

GTPase activity of RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane]

Orthologous Events
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