COPI-mediated anterograde transport

Stable Identifier
R-HSA-6807878
Type
Pathway
Species
Homo sapiens
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The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

Literature References
PubMed ID Title Journal Year
22013193 COPII and COPI traffic at the ER-Golgi interface

Sztul, E, Szul, T

Physiology (Bethesda) 2011
9288971 ER-to-Golgi transport visualized in living cells

Presley, JF, Lippincott-Schwartz, J, Hirschberg, K, Cole, NB, Zaal, KJ, Schroer, TA

Nature 1997
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Ferro-Novick, S, Miller, EA, Lord, C

Cold Spring Harb Perspect Biol 2013
23732476 Retrograde traffic from the Golgi to the endoplasmic reticulum

Spang, A

Cold Spring Harb Perspect Biol 2013
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R

J Cell Sci 2000
8334707 Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

Scheel, J, Hauri, HP, Griffiths, G, Horstmann, H, Kreis, TE, Pepperkok, R

Cell 1993
9323141 Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI

Scales, SJ, Kreis, TE, Pepperkok, R

Cell 1997
15632110 Live imaging of bidirectional traffic from the ERGIC

Hauri, HP, Ben-Tekaya, H, Pepperkok, R, Miura, K

J. Cell. Sci. 2005
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