Reactome | ALDH3B2 oxidises HXAL to PALM

ALDH3B2 oxidises HXAL to PALM

Stable Identifier

R-HSA-6808464

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lipid droplet, cytosol

ReviewStatus

5/5

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ALDH3B2 (aldehyde dehydrogenase family 3 member B2), associated with cytosolic lipid droplets, catalyzes the NAD-dependent oxdidation of HXAL (hexadecanal) to PALM (palmitate). A geranylgeranylated cysteine residue mediates the enzyme's association with the lipid droplet (Kitamura et al. 2013, 2015).

Literature References

PubMed ID	Title	Journal	Year
23721920	Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1 Abe, K, Nakahara, K, Ohno, Y, Kitamura, T, Kihara, A, Naganuma, T	Biochim. Biophys. Acta	2013
25286108	Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification Takagi, S, Kitamura, T, Kihara, A, Naganuma, T	Biochem. J.	2015