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GPI-CD55 [Golgi membrane]
Stable Identifier
R-HSA-6808768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
GPI-CD55 [Golgi membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17927562
Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane
Kinoshita, T
,
Maeda, Y
,
Takida, S
Biochem. J.
2008
External Reference Information
External Reference
UniProt:P08174 CD55
Gene Names
CD55, CR, DAF
Chain
signal peptide:1-34, chain:35-353, propeptide:354-381
Reference Genes
BioGPS Gene:1604 CD55
COSMIC (genes):CD55 CD55
CTD Gene:1604 CD55
dbSNP Gene:1604 CD55
ENSEMBL:ENSG00000196352 CD55
ENSEMBL_homo_sapiens_GENE:ENSG00000196352.18 CD55
HGNC:2665 CD55
KEGG Gene (Homo sapiens):1604 CD55
Monarch:1604 CD55
NCBI Gene:1604 CD55
OMIM:125240 CD55
UCSC:P08174 CD55
Reference Transcript
RefSeq:NM_001114752.2 CD55
RefSeq:NM_001300904.1 CD55
RefSeq:NM_000574.4 CD55
RefSeq:NM_001300903.1 CD55
Other Identifiers
11728701_a_at
11746180_a_at
11752832_x_at
11755084_x_at
11762060_x_at
11762726_x_at
1555950_3p_a_at
1555950_PM_a_at
1555950_a_at
1604
16676764
201925_PM_s_at
201925_s_at
201926_PM_s_at
201926_s_at
2377230
2377231
2377232
2377236
2377239
2377241
2377242
2377245
2377247
2377255
2377258
2377262
2377268
2377269
2377270
2377271
2377272
39695_at
7909332
A_14_P119189
A_14_P201810
A_23_P374862
A_24_P188377
GE61268
GO:0000139
GO:0001618
GO:0002376
GO:0002726
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005886
GO:0006958
GO:0007155
GO:0007204
GO:0008289
GO:0009986
GO:0016020
GO:0023052
GO:0030133
GO:0030449
GO:0030667
GO:0031410
GO:0031664
GO:0033116
GO:0043226
GO:0045087
GO:0045121
GO:0045730
GO:0045916
GO:0046718
GO:0070062
GO:0098542
GO:0098552
GO:0101003
GO:1903659
GO:2000516
GO:2000563
HMNXSV003018773
ILMN_1800540
M31516_s_at
PH_hs_0024773
TC01001736.hg
g10835142_3p_a_at
g12654888_3p_a_at
Participates
as a member of
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
Other forms of this molecule
CD55 [extracellular region]
GPI-CD55 [transport vesicle]
GPI-CD55 [endoplasmic reticulum-Golgi intermediate compartment membrane]
CD55 [ficolin-1-rich granule membrane]
CD55 [secretory granule membrane]
CD55 [plasma membrane]
Inferred To
apoh [Golgi membrane]
(Xenopus tropicalis)
CD55 [Golgi membrane]
(Bos taurus)
CD55 [Golgi membrane]
(Canis familiaris)
CD55 [Golgi membrane]
(Sus scrofa)
cfh-1 [Golgi membrane]
(Caenorhabditis elegans)
Cd55 [Golgi membrane]
(Mus musculus)
Cd55 [Golgi membrane]
(Rattus norvegicus)
Homologues of GPI-CD55 [Golgi membrane]
(Caenorhabditis elegans)
Homologues of GPI-CD55 [Golgi membrane]
(Drosophila melanogaster)
Homologues of GPI-CD55 [Golgi membrane]
(Xenopus tropicalis)
arc3 [Golgi membrane]
(Xenopus tropicalis)
Hasp [Golgi membrane]
(Drosophila melanogaster)
hig [Golgi membrane]
(Drosophila melanogaster)
GPI-CD55 [Golgi membrane]
(Caenorhabditis elegans)
GPI-CD55 [Golgi membrane]
(Gallus gallus)
fw [Golgi membrane]
(Drosophila melanogaster)
Modified Residues
Name
L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 353
Coordinate
353
Modification
GPI-anchor amidated amino acid carboxyl end residue(1−)
PsiMod Name
L-serine amide
PsiMod Definition
A protein modification that effectively converts an L-serine residue to L-serine amide.
Cross References
RefSeq
NP_001287833.1
,
NP_000565.1
,
NP_001108224.1
,
NP_001287832.1
Guide to Pharmacology - Targets
3246
OpenTargets
ENSG00000196352
HPA
ENSG00000196352-CD55
GeneCards
P08174
Ensembl
ENSP00000356031
,
ENSG00000196352
,
ENSP00000496251
,
ENST00000314754
,
ENSP00000495518
,
ENST00000367064
,
ENSP00000316333
,
ENST00000644836
,
ENST00000645323
PRO
P08174
Pharos - Targets
P08174
PDB
7DO4
,
1H2P
,
1UOT
,
1H2Q
,
6ILJ
,
2QZD
,
1OJV
,
7C9W
,
6ILK
,
1OJW
,
2C8I
,
2QZF
,
1M11
,
1OK1
,
1NWV
,
1H03
,
8K9R
,
1OK2
,
1OJY
,
1H04
,
7VY6
,
2QZH
,
3J24
,
1OK3
,
8B8R
,
7VY5
,
1UPN
,
8K9T
,
1OK9
,
3IYP
,
5FOA
,
6LA5
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