Reactome | KDELR2 [Golgi membrane]

KDELR2 [Golgi membrane]

Stable Identifier

R-HSA-6808784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33947 KDELR2

Gene Names

KDELR2, ERD2.2

Chain

chain:1-212

Reference Genes

BioGPS Gene:11014 KDELR2

COSMIC (genes):KDELR2 KDELR2

CTD Gene:11014 KDELR2

dbSNP Gene:11014 KDELR2

ENSEMBL:ENSG00000136240 KDELR2

ENSEMBL_homo_sapiens_GENE:ENSG00000136240.10 KDELR2

HGNC:6305 KDELR2

KEGG Gene (Homo sapiens):11014 KDELR2

Monarch:11014 KDELR2

NCBI Gene:11014 KDELR2

OMIM:609024 KDELR2

UCSC:P33947 KDELR2

Reference Transcript

Other Identifiers

11014

11715573_s_at

11715574_a_at

11756019_a_at

11756141_s_at

17055039

200698_PM_at

200698_at

200699_PM_at

200699_at

200700_PM_s_at

200700_s_at

3037386

3037387

3037388

3037389

3037390

3037391

3037392

3037393

3037394

3037396

3037397

3037399

3037400

3037406

3037411

3037412

39080_at

8138108

A_23_P19936

A_23_P19938

A_24_P410686

A_24_P42517

GE61465

GO:0000139

GO:0005046

GO:0005783

GO:0005789

GO:0005794

GO:0005801

GO:0006621

GO:0006888

GO:0006890

GO:0015031

GO:0016020

GO:0016192

GO:0030133

GO:0030663

GO:0031410

GO:0035437

GO:0043226

GO:0046923

HMNXSV003004585

Hs.118778.0.S2_3p_at

Hs.118778.0.S3_3p_at

Hs.118778.0.S3_3p_s_at

ILMN_1724293

M88458_at

PH_hs_0026119

PH_hs_0036045

TC07003350.hg

g8051609_3p_a_at

Participates

as a member of

Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)

as a candidate of

ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)

Other forms of this molecule

KDELR2 [endoplasmic reticulum membrane]

KDELR2 [transport vesicle]

KDELR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Inferred To

erd-2.2 [Golgi membrane] (Caenorhabditis elegans)

erd2 [Golgi membrane] (Schizosaccharomyces pombe)

KdelR [Golgi membrane] (Drosophila melanogaster)

kdelr2b [Golgi membrane] (Danio rerio)

ERD2 [Golgi membrane] (Plasmodium falciparum)

ERD2 [Golgi membrane] (Saccharomyces cerevisiae)

Kdelr2 [Golgi membrane] (Mus musculus)

Kdelr2 [Golgi membrane] (Rattus norvegicus)

KDELR2 [Golgi membrane] (Bos taurus)

KDELR2 [Golgi membrane] (Canis familiaris)

KDELR2 [Golgi membrane] (Gallus gallus)

KDELR2 [Golgi membrane] (Sus scrofa)

kdelr [Golgi membrane] (Dictyostelium discoideum)

kdelr2 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_006845.1, NP_001094073.1

OpenTargets

ENSG00000136240

GeneCards

P33947

HPA

ENSG00000136240-KDELR2

Ensembl

ENSP00000420501, ENSG00000136240, ENST00000258739, ENST00000490996, ENSP00000258739

PRO

P33947

Pharos - Targets

P33947

Cite Us!