Reactome | cis-Golgi cis-SNARE binds NSF and SNAPs

cis-Golgi cis-SNARE binds NSF and SNAPs

Stable Identifier

R-HSA-6809014

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009).

Literature References

PubMed ID	Title	Journal	Year
8620540	Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles Mayer, A, Wickner, W, Haas, A	Cell	1996
8221884	A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion Söllner, T, Bennett, MK, Whiteheart, SW, Scheller, RH, Rothman, JE	Cell	1993
19164740	Membrane fusion: grappling with SNARE and SM proteins Südhof, TC, Rothman, JE	Science	2009
16912714	SNAREs--engines for membrane fusion Jahn, R, Scheller, RH	Nat. Rev. Mol. Cell Biol.	2006