NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009).
Otto, H, Hanson, PI, Jahn, R
Mayer, A, Wickner, W, Haas, A
Shah, N, Colbert, KN, Enos, MD, Herschlag, D, Weis, WI
Yu, RC, Jahn, R, Brunger, AT
Whiteheart, SW, Matveeva, EA
Südhof, TC, Rothman, JE
Zhao, C, Smith, EC, Whiteheart, SW
Müller, JM, Rabouille, C, Newman, R, Shorter, J, Freemont, P, Schiavo, G, Warren, G, Shima, DT
Muller, JM, Shorter, J, Newman, R, Deinhardt, K, Sagiv, Y, Elazar, Z, Warren, G, Shima, DT
ATPase activity of cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane]
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