PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane

Stable Identifier
R-HSA-6809325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane
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Formation of a complex with MTMR9 results in a 4-fold increase of the phosphatidylinositol-3-phosphatase catalytic activity of MTMR8 and a modest increase of the catalytic activity of MTMR6 (Zou et al. 2012).
Literature References
PubMed ID Title Journal Year
22647598 Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, MP, Zhang, C, Zou, J

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-3-phosphate phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]

Physical Entity
MTMR6:MTMR9,MTMR8:MTMR9 [cytosol] (Homo sapiens)
Activity
phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438)
Orthologous Events
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)
Cross References
Rhea
Authored
Orlic-Milacic, M  (2015-11-13)
Reviewed
Rush, MG  (2017-01-10)
Created
Orlic-Milacic, M  (2015-11-11)
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