Reactome | THEM4 [cytosol]

THEM4 [cytosol]

Stable Identifier

R-HSA-6809345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

C-terminal modulator protein

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)
        
        AKT2:THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4 [cytosol] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)
        
        AKT2:THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5T1C6 THEM4

Gene Names

THEM4, CTMP

Chain

transit peptide:1-36, chain:37-240

Reference Genes

BioGPS Gene:117145 THEM4

COSMIC (genes):THEM4 THEM4

CTD Gene:117145 THEM4

dbSNP Gene:117145 THEM4

ENSEMBL:ENSG00000159445 THEM4

ENSEMBL_homo_sapiens_GENE:ENSG00000159445.13 THEM4

HGNC:17947 THEM4

KEGG Gene (Homo sapiens):117145 THEM4

Monarch:117145 THEM4

NCBI Gene:117145 THEM4

OMIM:606388 THEM4

UCSC:Q5T1C6 THEM4

Reference Transcript

RefSeq:NM_053055.4 THEM4

Other Identifiers

117145

11743092_at

11758326_s_at

1553118_PM_at

1553118_at

16693259

229253_3p_at

229253_PM_at

229253_at

243492_PM_at

243492_at

2435343

2435344

2435345

2435346

2435348

2435349

2435350

2435351

2435352

2435353

2435354

2435355

2435356

2435357

2435359

2435360

2435368

2435369

2435370

2435376

2435377

2435378

3407914

3407925

3625404

3625405

59980_at

7920114

82092_at

A_24_P928510

A_32_P66674

A_33_P3343432

GE56901

GE86079

GO:0003824

GO:0005515

GO:0005737

GO:0005739

GO:0005743

GO:0005758

GO:0005759

GO:0005829

GO:0005886

GO:0006629

GO:0006631

GO:0006915

GO:0007005

GO:0012501

GO:0016020

GO:0016290

GO:0016787

GO:0023052

GO:0032587

GO:0042995

GO:0043226

GO:0043491

GO:0061024

GO:0102991

GO:1902108

HMNXSV003010692

Hs.266155.0.A1_3p_x_at

Hs2.293691.1.S1_3p_x_at

ILMN_1682120

PH_hs_0029658

PH_hs_0032546

TC01003238.hg

Participates

as a member of

THEM4,TRIB3 [cytosol] (Homo sapiens)

Other forms of this molecule

THEM4 [mitochondrial matrix]

THEM4 [plasma membrane]

Inferred To

THEM4 [cytosol] (Bos taurus)

THEM4 [cytosol] (Dictyostelium discoideum)

THEM4 [cytosol] (Mus musculus)

THEM4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_444283.2

OpenTargets

ENSG00000159445

IntEnz

3.1.2.2

HPA

ENSG00000159445-THEM4

GeneCards

Q5T1C6

Ensembl

ENSG00000159445, ENSP00000357804, ENST00000368814

PRO

Q5T1C6

Pharos - Targets

Q5T1C6

PDB

4AE8, 4GAH

HMDB Protein

HMDBP11976

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.734	4
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.527	2
UniProt:P11182 DBT	11	DBT [cytosol] (R-HSA-9714663) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051)	0.527	2

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