Reactome | KRTAP1-1 [cytosol]

KRTAP1-1 [cytosol]

Stable Identifier

R-HSA-6809855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 1-1, KRA11_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-1 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07627 KRTAP1-1

Gene Names

KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1

Chain

chain:1-177

Reference Genes

BioGPS Gene:81851 KRTAP1-1

COSMIC (genes):KRTAP1-1 KRTAP1-1

CTD Gene:81851 KRTAP1-1

dbSNP Gene:81851 KRTAP1-1

ENSEMBL:ENSG00000188581 KRTAP1-1

HGNC:16772 KRTAP1-1

Monarch:81851 KRTAP1-1

NCBI Gene:81851 KRTAP1-1

OMIM:608819 KRTAP1-1

UCSC:Q07627 KRTAP1-1

Reference Transcript

RefSeq:NM_030967.2 KRTAP1-1

Other Identifiers

11738405_a_at

11738406_x_at

11753499_a_at

16844572

220976_PM_s_at

220976_s_at

3756691

3756696

3756697

3756698

3756699

3756700

3756701

3756702

8015196

8019578

81851

A_23_P141624

A_24_P151005

GE483411

GO:0005515

GO:0005829

GO:0005882

GO:0008150

GO:0045095

HMNXSV003048325

Hs.247935.0.S1_3p_s_at

ILMN_1657962

ILMN_1669119

ILMN_2209260

PH_hs_0013128

TC17001482.hg

TC17002903.hg

X63337_at

g13569941_3p_s_at

Participates

as a member of

KRTAP1s [cytosol] (Homo sapiens)

Inferred To

Homologues of KRTAP1-1 [cytosol] (Sus scrofa)

LOC100523275 [cytosol] (Sus scrofa)

Krtap1-3 [cytosol] (Mus musculus)

Krtap1-3 [cytosol] (Rattus norvegicus)

LOC102164863 [cytosol] (Sus scrofa)

KRTAP1-1 [cytosol] (Bos taurus)

KRTAP1-1 [cytosol] (Sus scrofa)

LOC102151604 [cytosol] (Canis familiaris)

Cross References

ENSEMBL

ENST00000573871, ENST00000306271, ENSP00000305975, ENSP00000460787

OpenTargets

ENSG00000188581

HPA

ENSG00000188581-KRTAP1-1

PRO

Q07627

Pharos - Targets

Q07627

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q9NP91 SLC6A20	2	SLC6A20 [plasma membrane] (R-HSA-352058) SLC6A20 T199M [plasma membrane] (R-HSA-5660705)	0.556	3
UniProt:O75093 SLIT1	1	SLIT1 [extracellular region] (R-HSA-204359)	0.556	3
UniProt:Q9Y5Y2 NUBP2	1	NUBP2 [cytosol] (R-HSA-2564767)	0.556	3
UniProt:P09603 CSF1	4	CSF1 [endoplasmic reticulum lumen] (R-HSA-8956778) p-CSF1 [endoplasmic reticulum lumen] (R-HSA-8956881) CSF1 [extracellular region] (R-HSA-9009484) CSF1 [plasma membrane] (R-HSA-389148)	0.556	3
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.556	3
UniProt:P62857 RPS28	2	RPS28 [cytosol] (R-HSA-72365) RPS28 [nucleoplasm] (R-HSA-6791202)	0.556	3
UniProt:O60259 KLK8	3	proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833) KLK8 propeptide [extracellular region] (R-HSA-8850829)	0.556	3
UniProt:Q9UBP5 HEY2	1	HEY2 [nucleoplasm] (R-HSA-1606745)	0.556	3
UniProt:P01308 INS	20	6xHC-INS(25-110) [Golgi lumen] (R-HSA-264890) 6xHC-INS(25-110) [secretory granule lumen] (R-HSA-264984) 2xHC-INS(25-56) [secretory granule lumen] (R-HSA-9023201) INS(57-89) [secretory granule lumen] (R-HSA-9023172) 4xHC-INS(57-110) [secretory granule lumen] (R-HSA-9023174) 6xHC-INS(25-110) [endoplasmic reticulum lumen] (R-HSA-265075) INS(57-87) [extracellular region] (R-HSA-265157) C Peptide [secretory granule lumen] (R-HSA-265011) 4xHC-INS(90-110) [secretory granule lumen] (R-HSA-264971) 2xHC-INS(25-54) [secretory granule lumen] (R-HSA-264902) INS(25-110) [endoplasmic reticulum lumen] (R-HSA-264893) Insulin Aspart B Chain [extracellular region] (R-HSA-429393) Insulin Humalog B Chain [extracellular region] (R-HSA-429397) Insulin Glulisine B Chain [extracellular region] (R-HSA-429465) 2xHC-Myri-INS(25-53) [extracellular region] (R-HSA-429343) Insulin Glargine A Chain [extracellular region] (R-HSA-429369) Insulin Glargine B Chain [extracellular region] (R-HSA-429347) 2xHC-INS(25-54) [extracellular region] (R-HSA-74673) 4xHC-INS(90-110) [extracellular region] (R-HSA-74672) INS(25-54) [endosome lumen] (R-HSA-141723)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.556	3
UniProt:P43353 ALDH3B1	3	ALDH3B1 [secretory granule membrane] (R-HSA-6801023) ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [specific granule membrane] (R-HSA-6799510)	0.556	3
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.556	3
UniProt:P07438 MT1B	1	MT1B [cytosol] (R-HSA-5660371)	0.556	3
UniProt:O96014 WNT11	9	N4GlycoAsn-PalmS WNT11 [extracellular region] (R-HSA-3247797) N4GlycoAsn-PalmS WNT11 [plasma membrane] (R-HSA-3247792) N4GlycoAsn-PalmS WNT11 [Golgi lumen] (R-HSA-3247823) N4GlycoAsn-PalmS WNT11 [endoplasmic reticulum lumen] (R-HSA-3238335) N4GlycoAsn-WNT11 [endoplasmic reticulum lumen] (R-HSA-3238222) WNT11 [endoplasmic reticulum lumen] (R-HSA-3238281) N4GlycoAsn-PalmS WNT11 [endocytic vesicle membrane] (R-HSA-3781987) N4GlycoAsn-PalmS WNT11 [extracellular exosome] (R-HSA-3781980) WNT11 [extracellular region] (R-HSA-517473)	0.556	3
UniProt:Q9UPY5 SLC7A11	1	SLC7A11 [plasma membrane] (R-HSA-378515)	0.556	3
UniProt:Q8N370 SLC43A2	1	SLC43A2 [plasma membrane] (R-HSA-352109)	0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	3
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:Q9UBR2 CTSZ	9	CTSZ [specific granule lumen] (R-HSA-6801304) CTSZ [extracellular region] (R-HSA-6801569) CTSZ [ficolin-1-rich granule lumen] (R-HSA-6801318) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen] (R-HSA-5689431) (Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689727) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689730) CTSZ [plasma membrane] (R-HSA-2022345) CTSZ [lysosomal lumen] (R-HSA-429814) CTSZ [Golgi lumen] (R-HSA-434321)	0.556	3
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.556	3
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3

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