PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane

Stable Identifier
R-HSA-6809975
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Formation of the complex with SBF2 (MTMR13) dramatically increases phosphatidylinositol-3-phosphatase catalytic activity of MTMR2. Since SBF2 sequesters MTRM2 from endosome membranes, the MTMR2 presumably acts on the plasma membrane-associated substrate (Berger et al. 2006).
Literature References
PubMed ID Title Journal Year
16399794 Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2

Volkmer, B, Berger, I, Tersar, K, Berger, P, Suter, U, Schaffitzel, C

Hum. Mol. Genet. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-3-phosphate phosphatase activity of MTMR2:SBF2 Tetramer [cytosol]

Physical Entity
MTMR2:SBF2 Tetramer [cytosol] (Homo sapiens)
Activity
phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438)
Inferred From
PI3P is dephosphorylated to PI by the Mtmr2:Sbf2 tetramer at the plasma membrane (Mus musculus)
Cross References
Rhea
Authored
Orlic-Milacic, M  (2015-11-13)
Reviewed
Rush, MG  (2017-01-10)
Created
Orlic-Milacic, M  (2015-11-13)
Cite Us!