Reactome | GOLGB1 [Golgi membrane]

GOLGB1 [Golgi membrane]

Stable Identifier

R-HSA-6810004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Golgin subfamily B member 1, 372 kDa Golgi complex-associated protein, GCP372, Giantin, Macrogolgin

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - ACBD3 binds GOLGB1 (Homo sapiens)
        
        ACBD3:GOLGB1 dimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)
        
        GOLGB1 homodimer [Golgi membrane] (Homo sapiens)
        
        GOLGB1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14789 GOLGB1

Gene Names

GOLGB1

Chain

chain:1-3259

Reference Genes

BioGPS Gene:2804 GOLGB1

COSMIC (genes):GOLGB1 GOLGB1

CTD Gene:2804 GOLGB1

dbSNP Gene:2804 GOLGB1

ENSEMBL:ENSG00000173230 GOLGB1

ENSEMBL_homo_sapiens_GENE:ENSG00000173230.17 GOLGB1

HGNC:4429 GOLGB1

KEGG Gene (Homo sapiens):2804 GOLGB1

Monarch:2804 GOLGB1

NCBI Gene:2804 GOLGB1

OMIM:602500 GOLGB1

UCSC:Q14789 GOLGB1

Reference Transcript

Other Identifiers

11754456_a_at

11754457_a_at

16958014

201056_PM_at

201056_at

201057_PM_s_at

201057_s_at

2691719

2691720

2691721

2691722

2691723

2691724

2691728

2691730

2691731

2691733

2691736

2691737

2691738

2691739

2691745

2691746

2691747

2691748

2691749

2691750

2691751

2691752

2691753

2691754

2691755

2691756

2691757

2691758

2691760

2691761

2691765

2691766

2691767

2691768

2691769

2691770

2691772

2691773

2691775

2691785

2691786

2804

37655_at

74699_s_at

8089930

A_23_P135787

A_24_P240137

A_33_P3289705

GE59999

GO:0000139

GO:0003677

GO:0003723

GO:0005515

GO:0005793

GO:0005794

GO:0005795

GO:0005801

GO:0005829

GO:0006351

GO:0006355

GO:0007030

GO:0016020

GO:0043226

GO:0043565

GO:1905793

HMNXSV003045184

Hs.7844.0.S2_3p_at

ILMN_1747935

PH_hs_0028477

TC03001698.hg

X75304_at

g4758453_3p_a_at

Participates

as a component of

GOLGB1 homodimer [Golgi membrane] (Homo sapiens)

Other forms of this molecule

GOLGB1(1-2893)-FLT3(591-993) fusion [cytosol]

GOLGB1(1-2893)-p-5Y-FLT3(591-993) fusion [cytosol]

Inferred To

GOLGB1 [Golgi membrane] (Bos taurus)

GOLGB1 [Golgi membrane] (Canis familiaris)

GOLGB1 [Golgi membrane] (Gallus gallus)

GOLGB1 [Golgi membrane] (Sus scrofa)

golgb1 [Golgi membrane] (Xenopus tropicalis)

Golgb1 [Golgi membrane] (Mus musculus)

Golgb1 [Golgi membrane] (Rattus norvegicus)

Ghost homologue of GOLGB1 [Golgi membrane] (Caenorhabditis elegans)

Ghost homologue of GOLGB1 [Golgi membrane] (Dictyostelium discoideum)

Ghost homologue of GOLGB1 [Golgi membrane] (Drosophila melanogaster)

Ghost homologue of GOLGB1 [Golgi membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001243417.1, NP_004478.3, XP_005247428.1, NP_001243416.1, NP_001243415.1, XP_011511001.1

OpenTargets

ENSG00000173230

GeneCards

Q14789

HPA

ENSG00000173230-GOLGB1

Ensembl

ENST00000393667, ENST00000340645, ENSP00000377275, ENSP00000341848, ENSG00000173230

PRO

Q14789

Pharos - Targets

Q14789

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [Golgi membrane] (R-HSA-6808804)	0.527	4