Reactome | KRTAP5-9 [cytosol]

KRTAP5-9 [cytosol]

Stable Identifier

R-HSA-6810265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 5-9, KRA59_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP5s [cytosol] (Homo sapiens)
        
        KRTAP5-9 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP5s [cytosol] (Homo sapiens)
        
        KRTAP5-9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P26371 KRTAP5-9

Gene Names

KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1

Chain

chain:1-169

Reference Genes

BioGPS Gene:3846 KRTAP5-9

COSMIC (genes):KRTAP5-9 KRTAP5-9

CTD Gene:3846 KRTAP5-9

dbSNP Gene:3846 KRTAP5-9

ENSEMBL:ENSG00000254997 KRTAP5-9

ENSEMBL:ENSG00000254997.4 KRTAP5-9

HGNC:23604 KRTAP5-9

KEGG Gene (Homo sapiens):3846 KRTAP5-9

Monarch:3846 KRTAP5-9

NCBI Gene:3846 KRTAP5-9

OMIM:148021 KRTAP5-9

UCSC:P26371 KRTAP5-9

Reference Transcript

RefSeq:NM_005553.3 KRTAP5-9

Other Identifiers

11740533_at

16728509

214517_PM_at

214517_at

3316967

3316971

3316994

3339057

3339058

3339059

3339060

3339061

3339062

3339063

3358923

34555_at

3846

7942261

A_14_P136975

A_23_P13048

A_33_P3271087

GE59901

GE85721

GO:0005515

GO:0005829

GO:0005856

GO:0005882

GO:0008544

GO:0042802

GO:0043226

GO:0048856

HMNXSV003046655

Hs.2743.0.S1_3p_at

ILMN_1766565

PH_hs_0028713

PH_hs_0030890

TC11000737.hg

X63755_at

g10567823_3p_s_at

Participates

as a member of

KRTAP5s [cytosol] (Homo sapiens)

Inferred To

Krtap5-2 [cytosol] (Mus musculus)

Gm29735 [cytosol] (Mus musculus)

Gm45618 [cytosol] (Mus musculus)

KRTAP5-9 [cytosol] (Canis familiaris)

KRTAP5-9 [cytosol] (Rattus norvegicus)

KRTAP5-9 [cytosol] (Sus scrofa)

KRTAP5-9 [cytosol] (Xenopus tropicalis)

Krtap5-1 [cytosol] (Mus musculus)

Gm40460 [cytosol] (Mus musculus)

Gm10153 [cytosol] (Mus musculus)

Gm39115 [cytosol] (Mus musculus)

Gm45337 [cytosol] (Mus musculus)

Gm4559 [cytosol] (Mus musculus)

Krtap5-8 [cytosol] (Rattus norvegicus)

Gm4553 [cytosol] (Mus musculus)

Gm7579 [cytosol] (Mus musculus)

Krtap5-4 [cytosol] (Mus musculus)

Homologues of KRTAP5-9 [cytosol] (Mus musculus)

Homologues of KRTAP5-9 [cytosol] (Rattus norvegicus)

Homologues of KRTAP5-9 [cytosol] (Xenopus tropicalis)

Krtap5-5 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_005544.4

OpenTargets

ENSG00000254997

HPA

ENSG00000254997-KRTAP5-9

GeneCards

P26371

Ensembl

ENSG00000254997, ENST00000528743, ENSP00000431443

PRO

P26371

Pharos - Targets

P26371

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBR2 CTSZ	9	(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen] (R-HSA-5689431) (Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689727) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689730) CTSZ [ficolin-1-rich granule lumen] (R-HSA-6801318) CTSZ [extracellular region] (R-HSA-6801569) CTSZ [specific granule lumen] (R-HSA-6801304) CTSZ [plasma membrane] (R-HSA-2022345) CTSZ [lysosomal lumen] (R-HSA-429814) CTSZ [Golgi lumen] (R-HSA-434321)	0.83	8
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.742	5
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.735	12
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.718	6
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.718	6
UniProt:Q8WUK0 PTPMT1	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.718	6
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.718	8
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:Q9HB63 NTN4	1	NTN4 [plasma membrane] (R-HSA-561258)	0.666	4
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:P06850 CRH	1	CRH [extracellular region] (R-HSA-420146)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q9UBP5 HEY2	1	HEY2 [nucleoplasm] (R-HSA-1606745)	0.556	3
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:O43597 SPRY2	8	p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629)	0.556	3
UniProt:Q9UBX3 SLC25A10	1	SLC25A10 [mitochondrial inner membrane] (R-HSA-372848)	0.556	3
UniProt:Q92824 PCSK5	2	PCSK5 [extracellular region] (R-HSA-6784682) PCSK5(115-913) [Golgi lumen] (R-HSA-166558)	0.556	3
UniProt:Q8N339 MT1M	1	MT1M [cytosol] (R-HSA-5660422)	0.556	3
UniProt:P43353 ALDH3B1	3	ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [secretory granule membrane] (R-HSA-6801023) ALDH3B1 [specific granule membrane] (R-HSA-6799510)	0.556	3
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.556	3
UniProt:P50747 HLCS	8	HLCS [cytosol] (R-HSA-2993867) HLCS L216R [cytosol] (R-HSA-3325513) HLCS D571N [cytosol] (R-HSA-3325499) HLCS L237P [cytosol] (R-HSA-3325514) HLCS V550M [cytosol] (R-HSA-3325460) HLCS G261Vfs*20 [cytosol] (R-HSA-3325463) HLCS R508W [cytosol] (R-HSA-3325442) HLCS G581S [cytosol] (R-HSA-3325506)	0.556	3
UniProt:Q86YT5 SLC13A5	1	SLC13A5 [plasma membrane] (R-HSA-433135)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.556	3
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q6UWV6 ENPP7	1	ENPP7 [plasma membrane] (R-HSA-1631583)	0.556	3
UniProt:Q96FE5 LINGO1	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.556	3
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:O60259 KLK8	3	KLK8 propeptide [extracellular region] (R-HSA-8850829) proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3

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