Reactome | KRTAP6-3 [cytosol]

KRTAP6-3 [cytosol]

Stable Identifier

R-HSA-6810281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 6-3, KRA63_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP6s [cytosol] (Homo sapiens)
        
        KRTAP6-3 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP6s [cytosol] (Homo sapiens)
        
        KRTAP6-3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q3LI67 KRTAP6-3

Gene Names

KRTAP6-3, KAP6.3

Chain

chain:1-110

Reference Genes

BioGPS Gene:337968 KRTAP6-3

COSMIC (genes):KRTAP6-3 KRTAP6-3

CTD Gene:337968 KRTAP6-3

dbSNP Gene:337968 KRTAP6-3

ENSEMBL:ENSG00000212938 KRTAP6-3

HGNC:18933 KRTAP6-3

Monarch:337968 KRTAP6-3

NCBI Gene:337968 KRTAP6-3

UCSC:Q3LI67 KRTAP6-3

Reference Transcript

RefSeq:NM_181605.3 KRTAP6-3

Other Identifiers

11738442_at

16922070

337968

3917583

3917584

3917585

3917586

8068145

A_24_P391604

GO:0005515

GO:0005829

GO:0005882

GO:0031424

HMNXSV003010534

ILMN_1728440

PH_hs_0030511

TC21000104.hg

TC21000659.hg

Participates

as a member of

KRTAP6s [cytosol] (Homo sapiens)

Inferred To

ENSRNOG00000071041 [cytosol] (Rattus norvegicus)

Homologues of KRTAP6-3 [cytosol] (Bos taurus)

Homologues of KRTAP6-3 [cytosol] (Mus musculus)

Krtap6-1 [cytosol] (Mus musculus)

Krtap6-5 [cytosol] (Mus musculus)

LOC618359 [cytosol] (Bos taurus)

Krtap6-3 [cytosol] (Mus musculus)

LOC112446984 [cytosol] (Bos taurus)

Cross References

ENSEMBL

ENSP00000375482, ENST00000391624

OpenTargets

ENSG00000212938

HPA

ENSG00000212938-KRTAP6-3

PRO

Q3LI67

Pharos - Targets

Q3LI67

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.556	3
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:Q13207 TBX2	1	TBX2 [nucleoplasm] (R-HSA-9825814)	0.556	3
UniProt:Q9UBR2 CTSZ	9	CTSZ [specific granule lumen] (R-HSA-6801304) CTSZ [extracellular region] (R-HSA-6801569) CTSZ [ficolin-1-rich granule lumen] (R-HSA-6801318) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen] (R-HSA-5689431) (Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689727) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689730) CTSZ [plasma membrane] (R-HSA-2022345) CTSZ [lysosomal lumen] (R-HSA-429814) CTSZ [Golgi lumen] (R-HSA-434321)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.556	3
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:A8MTQ0 NOTO	1	NOTO [nucleoplasm] (R-HSA-9796216)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	5
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	6
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:O95947 TBX6	1	TBX6 [nucleoplasm] (R-HSA-9793377)	0.556	3
UniProt:O76082 SLC22A5	7	SLC22A5 [plasma membrane] (R-HSA-549319) SLC22A5 W132* [plasma membrane] (R-HSA-5625620) SLC22A5 R169Q [plasma membrane] (R-HSA-5625654) SLC22A5 R169W [plasma membrane] (R-HSA-5625686) SLC22A5 R254* [plasma membrane] (R-HSA-5625665) SLC22A5 G15W [plasma membrane] (R-HSA-5625680) SLC22A5 P478L [plasma membrane] (R-HSA-5625661)	0.556	3

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