Reactome | KRTAP10-8 [cytosol]

KRTAP10-8 [cytosol]

Stable Identifier

R-HSA-6810301

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 10-8, KR108_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP10s [cytosol] (Homo sapiens)
        
        KRTAP10-8 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP10s [cytosol] (Homo sapiens)
        
        KRTAP10-8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60410 KRTAP10-8

Gene Names

KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8

Chain

chain:1-259

Reference Genes

BioGPS Gene:386681 KRTAP10-8

COSMIC (genes):KRTAP10-8 KRTAP10-8

CTD Gene:386681 KRTAP10-8

dbSNP Gene:386681 KRTAP10-8

ENSEMBL:ENSG00000187766 KRTAP10-8

HGNC:20525 KRTAP10-8

Monarch:386681 KRTAP10-8

NCBI Gene:386681 KRTAP10-8

UCSC:P60410 KRTAP10-8

Reference Transcript

RefSeq:NM_198695.2 KRTAP10-8

Other Identifiers

11715321_x_at

16923656

386681

3923855

3923856

3923861

3923877

3934575

3934579

3934580

8069148

A_33_P3293760

GO:0005515

GO:0005829

GO:0005882

GO:0042802

GO:0045095

HMNXSV003011925

ILMN_1793716

PH_hs_0034603

TC21000232.hg

Participates

as a member of

KRTAP10s [cytosol] (Homo sapiens)

Inferred To

Krtap10-27 [cytosol] (Mus musculus)

Krtap10-32 [cytosol] (Mus musculus)

Krtap10-26 [cytosol] (Mus musculus)

Krtap10-33 [cytosol] (Mus musculus)

Krtap10-28 [cytosol] (Mus musculus)

LOC100623393 [cytosol] (Sus scrofa)

Krtap10-4 [cytosol] (Mus musculus)

Krtap10-25 [cytosol] (Mus musculus)

Krtap10-30 [cytosol] (Mus musculus)

Homologues of KRTAP10-8 [cytosol] (Bos taurus)

Homologues of KRTAP10-8 [cytosol] (Mus musculus)

Homologues of KRTAP10-8 [cytosol] (Rattus norvegicus)

Homologues of KRTAP10-8 [cytosol] (Sus scrofa)

Krtap10-29 [cytosol] (Mus musculus)

Krtap10-31 [cytosol] (Mus musculus)

Krtap10-24 [cytosol] (Mus musculus)

KRTAP10-8 [cytosol] (Bos taurus)

KRTAP10-8 [cytosol] (Sus scrofa)

Krtap10-23 [cytosol] (Mus musculus)

Krtap10-22 [cytosol] (Mus musculus)

Krtap10-9 [cytosol] (Rattus norvegicus)

Krtap10-10 [cytosol] (Mus musculus)

LOC102160031 [cytosol] (Sus scrofa)

LOC100622826 [cytosol] (Sus scrofa)

LOC100518807 [cytosol] (Sus scrofa)

Krtap10-21 [cytosol] (Mus musculus)

Krtap10-34 [cytosol] (Mus musculus)

Cross References

OpenTargets

ENSG00000187766

ENSEMBL

ENST00000334662, ENSP00000335565

HPA

ENSG00000187766-KRTAP10-8

PRO

P60410

Pharos - Targets

P60410

Interactors (70)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.718	6
UniProt:Q8WUK0 DUSP23	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.718	6
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.718	6
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.718	6
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.718	9
UniProt:Q9NP91 SLC6A20	2	SLC6A20 [plasma membrane] (R-HSA-352058) SLC6A20 T199M [plasma membrane] (R-HSA-5660705)	0.718	6
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.718	8
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.718	8
UniProt:Q9Y5W5 WIF1	1	WIF1 [extracellular region] (R-HSA-3769320)	0.718	6
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.718	6
UniProt:P43353 ALDH3B1	3	ALDH3B1 [secretory granule membrane] (R-HSA-6801023) ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [specific granule membrane] (R-HSA-6799510)	0.718	6
UniProt:Q9BSD3 RHNO1	1	RHNO1 [nucleoplasm] (R-HSA-5684880)	0.556	3
UniProt:P31785 IL2RG	4	IL2RG [endosome] (R-HSA-8983165) p-Y-IL2RG [cytosol] (R-HSA-9009721) p-Y-IL2RG [plasma membrane] (R-HSA-6786103) IL2RG [plasma membrane] (R-HSA-449139)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3
UniProt:Q92824 PCSK5	2	PCSK5 [extracellular region] (R-HSA-6784682) PCSK5(115-913) [Golgi lumen] (R-HSA-166558)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	5
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q99572 P2RX7	1	P2RX7 [plasma membrane] (R-HSA-877215)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q9UBX3 SLC25A10	1	SLC25A10 [mitochondrial inner membrane] (R-HSA-372848)	0.556	3
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:O96014 WNT11	9	N4GlycoAsn-PalmS WNT11 [extracellular region] (R-HSA-3247797) N4GlycoAsn-PalmS WNT11 [plasma membrane] (R-HSA-3247792) N4GlycoAsn-PalmS WNT11 [Golgi lumen] (R-HSA-3247823) N4GlycoAsn-PalmS WNT11 [endoplasmic reticulum lumen] (R-HSA-3238335) N4GlycoAsn-WNT11 [endoplasmic reticulum lumen] (R-HSA-3238222) WNT11 [endoplasmic reticulum lumen] (R-HSA-3238281) N4GlycoAsn-PalmS WNT11 [endocytic vesicle membrane] (R-HSA-3781987) N4GlycoAsn-PalmS WNT11 [extracellular exosome] (R-HSA-3781980) WNT11 [extracellular region] (R-HSA-517473)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.556	3
UniProt:Q86YT5 SLC13A5	1	SLC13A5 [plasma membrane] (R-HSA-433135)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P19544 WT1	1	WT1 [nucleoplasm] (R-HSA-452420)	0.556	3
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	3
UniProt:O75093 SLIT1	1	SLIT1 [extracellular region] (R-HSA-204359)	0.556	3
UniProt:Q96SQ9 CYP2S1	1	CYP2S1 [endoplasmic reticulum membrane] (R-HSA-2980785)	0.556	3
UniProt:P06850 CRH	1	CRH [extracellular region] (R-HSA-420146)	0.556	3
UniProt:P09603 CSF1	4	CSF1 [endoplasmic reticulum lumen] (R-HSA-8956778) p-CSF1 [endoplasmic reticulum lumen] (R-HSA-8956881) CSF1 [extracellular region] (R-HSA-9009484) CSF1 [plasma membrane] (R-HSA-389148)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:P62857 RPS28	2	RPS28 [cytosol] (R-HSA-72365) RPS28 [nucleoplasm] (R-HSA-6791202)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:O60259 KLK8	3	proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833) KLK8 propeptide [extracellular region] (R-HSA-8850829)	0.556	3
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.556	3
UniProt:Q14061 COX17	2	4xHC-COX17 [mitochondrial intermembrane space] (R-HSA-1307785) COX17 [mitochondrial intermembrane space] (R-HSA-1307788)	0.556	3
UniProt:P22301 IL10	1	IL10 [extracellular region] (R-HSA-447125)	0.556	3
UniProt:Q9HB63 NTN4	1	NTN4 [plasma membrane] (R-HSA-561258)	0.556	3
UniProt:P15514 AREG	5	AREG(101-187) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628809) AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689774) AREG precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689771) AREG precursor [endoplasmic reticulum membrane] (R-HSA-5689438) AREG(101-187) [extracellular region] (R-HSA-9624190)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:P42892 ECE1	1	ECE1 [plasma membrane] (R-HSA-8876866)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q86VD7 SLC25A42	1	SLC25A42 [mitochondrial inner membrane] (R-HSA-5216033)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:O43602 DCX	1	DCX [cytosol] (R-HSA-430060)	0.556	3
UniProt:Q13875 MOBP	1	MOBP [cytosol] (R-HSA-9022884)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P20336 RAB3A	9	RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [cytosol] (R-HSA-8870410) GGC-RAB3A [cytosol] (R-HSA-8870429) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3

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