Reactome | TMEM55B [late endosome membrane]

TMEM55B [late endosome membrane]

Stable Identifier

R-HSA-6810395

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

late endosome membrane

Synonyms

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Transmembrane protein 55B, PtdIns-4,5-P2 4-Ptase I

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        TMEM55B translocates to the nucleus (Homo sapiens)
        
        TMEM55B [late endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86T03 TMEM55B

Gene Names

TMEM55B, C14orf9, PIP4P1

Chain

chain:1-277

Reference Genes

BioGPS Gene:90809 TMEM55B

COSMIC (genes):PIP4P1 TMEM55B

CTD Gene:90809 TMEM55B

dbSNP Gene:90809 TMEM55B

ENSEMBL:ENSG00000165782 TMEM55B

HGNC:19299 TMEM55B

KEGG:hsa:90809 TMEM55B

Monarch:90809 TMEM55B

NCBI Gene:90809 TMEM55B

OMIM:609865 TMEM55B

UCSC:Q86T03 TMEM55B

Reference Transcript

Other Identifiers

11724803_at

16790059

225287_PM_s_at

225287_s_at

3555493

3555494

3555495

3555496

3555497

3555498

3555499

3555500

3555501

3555502

3555503

3555504

3555505

3555506

3555507

3555508

3555509

3555510

3555511

3555512

46241_at

7977584

90809

A_23_P48610

GE566375

GE56795

GO:0003824

GO:0005515

GO:0005654

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0006629

GO:0006644

GO:0006991

GO:0008203

GO:0016020

GO:0016787

GO:0030670

GO:0031410

GO:0031902

GO:0032418

GO:0034597

GO:0043226

GO:0046856

GO:0065003

GO:0070070

GO:1901796

GO:1904263

HMNXSV003027385

Hs.318693.0.S1_3p_s_at

ILMN_1770742

PH_hs_0027062

TC14000887.hg

Participates

as an input of

TMEM55B translocates to the nucleus (Homo sapiens)

Other forms of this molecule

TMEM55B [nucleoplasm]

Inferred To

PIP4P1 [late endosome membrane] (Canis familiaris)

PIP4P1 [late endosome membrane] (Sus scrofa)

Dmel\CG6707 [late endosome membrane] (Drosophila melanogaster)

Pip4p1 [late endosome membrane] (Mus musculus)

Pip4p1 [late endosome membrane] (Rattus norvegicus)

tmem55ba [late endosome membrane] (Danio rerio)

pipp-4p [late endosome membrane] (Caenorhabditis elegans)

pip4p1 [late endosome membrane] (Xenopus tropicalis)

TMEM55B [late endosome membrane] (Bos taurus)

Cross References

RefSeq

NP_653169.2, NP_001094284.1

ENSEMBL

ENST00000708815, ENST00000708818, ENST00000398020, ENSP00000381102, ENSP00000250489, ENST00000250489, ENSP00000517359, ENSP00000517357

OpenTargets

ENSG00000165782

HPA

ENSG00000165782-PIP4P1

PRO

Q86T03

Pharos - Targets

Q86T03

HMDB Protein

HMDBP07345

PDB

8OQH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:Q5EBL4-3 RILPL1			0.556	5
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P55327 TPD52	2	TPD52 [Golgi lumen] (R-HSA-434329) TPD52 [cytoplasmic vesicle lumen] (R-HSA-434210)	0.527	2
UniProt:Q8N4P2 IFT70B	2	TTC30B [ciliary tip] (R-HSA-5637970) TTC30B [cilium] (R-HSA-5637971)	0.508	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4