NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT

Stable Identifier
R-HSA-6810474
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT
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Coenzyme A (CoA-SH) and acyl-coenzyme A (acyl-CoA) can be degraded in peroxisomes by two members of the Nudix (nucleoside diphosphates linked to some moiety X) hydrolase superfamily; NUDT7 and NUDT19. NUDT19 hydrolyses free fatty acyl-CoA to form acyl-phosphopantetheine (acyl-PPANT) and 3′,5′-ADP. Human NUDT19 activity is inferred from mouse Nudt19 activity (Ofman et al. 2006).
Literature References
PubMed ID Title Journal Year
16185196 Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity

Speijer, D, Leen, R, Wanders, RJA, Ofman, R

Biochem. J. 2006
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Catalyst Activity

CoA pyrophosphatase activity of NUDT19 [peroxisomal matrix]

Physical Entity
NUDT19 [peroxisomal matrix] (Homo sapiens)
Activity
CoA pyrophosphatase activity (GO:0010945)
Orthologous Events
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Bos taurus)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Canis familiaris)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Gallus gallus)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)
NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Xenopus tropicalis)
Authored
Jassal, B  (2015-11-17)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-11-17)
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