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CLU(228-449) [extracellular region]
Stable Identifier
R-HSA-6810626
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Clusterin alpha chain, CLU
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
EPPIN protein complex binds bacteria (Homo sapiens)
EPC:bacterial surface [sperm plasma membrane] (Homo sapiens)
EPPIN:SEMG1:LTF:CLU [sperm plasma membrane] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
EPPIN:SEMG1:LTF:CLU [sperm plasma membrane] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
C7 binds C5b:C6 (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
C8 binds C5b:C6:C7 (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
C9 binds C5b:C6:C7:C8 (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
CLU [extracellular region] (Homo sapiens)
CLU(228-449) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10909 CLU
Gene Names
CLU, APOJ, CLI, KUB1, AAG4
Chain
signal peptide:1-22, chain:23-449, chain:23-227, chain:228-449
Reference Genes
BioGPS Gene:1191 CLU
COSMIC (genes):CLU CLU
CTD Gene:1191 CLU
dbSNP Gene:1191 CLU
ENSEMBL:ENSG00000120885 CLU
ENSEMBL_homo_sapiens_GENE:ENSG00000120885.22 CLU
HGNC:2095 CLU
KEGG Gene (Homo sapiens):1191 CLU
Monarch:1191 CLU
NCBI Gene:1191 CLU
OMIM:185430 CLU
UCSC:P10909 CLU
Reference Transcript
RefSeq:NM_001831.3 CLU
Other Identifiers
11715851_s_at
11756547_a_at
1191
17075731
208791_PM_at
208791_at
208792_PM_s_at
208792_s_at
222043_PM_at
222043_at
3129071
3129072
3129073
3129074
3129075
3129076
3129077
3129078
3129079
3129081
3129083
3129085
3129086
3129087
3129088
3129089
3129090
3129092
3129093
3129096
3129097
3129098
3129099
3129100
3129101
3129102
3129103
3129104
3129105
3129109
36780_at
43817_f_at
63969_f_at
75382_i_at
75384_f_at
80587_s_at
8149927
A_23_P215913
GE479016
GE61669
GE79935
GO:0000902
GO:0001540
GO:0001774
GO:0001836
GO:0002376
GO:0002434
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006457
GO:0006629
GO:0006886
GO:0006914
GO:0006915
GO:0006954
GO:0006956
GO:0006958
GO:0007005
GO:0008092
GO:0009615
GO:0009986
GO:0010628
GO:0012501
GO:0016020
GO:0016192
GO:0017038
GO:0023052
GO:0030154
GO:0030163
GO:0030312
GO:0031012
GO:0031093
GO:0031333
GO:0031334
GO:0031410
GO:0031625
GO:0031966
GO:0032286
GO:0032436
GO:0032760
GO:0032991
GO:0034366
GO:0042127
GO:0042583
GO:0042981
GO:0043065
GO:0043226
GO:0043231
GO:0043524
GO:0043691
GO:0044877
GO:0045087
GO:0045202
GO:0045429
GO:0048156
GO:0048260
GO:0048471
GO:0048856
GO:0050750
GO:0050821
GO:0051082
GO:0051087
GO:0051092
GO:0051131
GO:0051787
GO:0051788
GO:0061024
GO:0061077
GO:0061518
GO:0061740
GO:0062023
GO:0065003
GO:0070062
GO:0071944
GO:0072562
GO:0090201
GO:0097418
GO:0097440
GO:0098542
GO:0099020
GO:0140104
GO:0140597
GO:1900221
GO:1902004
GO:1902230
GO:1902430
GO:1902847
GO:1902998
GO:1903573
GO:1905907
GO:1905908
GO:2000060
HMNXSV003026147
HMNXSV003030892
Hs.75106.1.S1_3p_at
ILMN_1691483
ILMN_1798298
M63379_at
PH_hs_0025525
TC08001081.hg
TC08002263.hg
g180619_3p_a_at
g180619_3p_at
Participates
as a component of
CLU [extracellular region] (Homo sapiens)
Other forms of this molecule
CLU(23-449) [extracellular region]
CLU(23-449) [platelet alpha granule lumen]
CLU(23-227) [extracellular region]
Inferred To
Clu [extracellular region]
(Mus musculus)
Clu [extracellular region]
(Rattus norvegicus)
Ghost homologue of CLU(228-449) [extracellular region]
(Gallus gallus)
clu [extracellular region]
(Danio rerio)
clu [extracellular region]
(Xenopus tropicalis)
Homologues of CLU(228-449) [extracellular region]
(Sus scrofa)
CLU [extracellular region]
(Bos taurus)
CLU [extracellular region]
(Canis familiaris)
CLU [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001822.3
Guide to Pharmacology - Targets
3195
OpenTargets
ENSG00000120885
GeneCards
P10909
HPA
ENSG00000120885-CLU
Ensembl
ENSG00000120885
,
ENSP00000429620
,
ENSP00000315130
,
ENST00000523500
,
ENST00000316403
,
ENST00000405140
,
ENSP00000385419
PRO
P10909
Pharos - Targets
P10909
PDB
7ZEU
,
7ZET
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.662
4
UniProt:P30101 PDIA3
3
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.59
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P18509 ADCYAP1
4
ADCYAP1(132-158) [extracellular region]
(R-HSA-420144)
ADCYAP1(82-129) [extracellular region]
(R-HSA-420254)
ADCYAP1(132-169) [extracellular region]
(R-HSA-420282)
ADCYAP1(2-742) [Golgi membrane]
(R-HSA-187679)
0.543
4
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.524
2
UniProt:P37231 PPARG
2
monoSUMO1-K107,K395-PPARG [nucleoplasm]
(R-HSA-4717444)
PPARG [nucleoplasm]
(R-HSA-446172)
0.524
3
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